Phenylpropanoid conjugated iridoids with anti-malarial activity from the leaves of Morinda morindoides.
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DOI: 10.1007/s11418-021-01541-x
Abstract: Two phenylpropanoid-conjugated iridoids, deglucosyl gaertneroside (1) and morindoidin (2), were isolated from the leaves of Morinda morindoides (Rubiaceae) by activity-guided fractionation using an anti-malarial activity assay. The known related iridoids molucidin (3) and prismatomerin (4),… read more here.
Keywords: malarial activity; anti malarial; phenylpropanoid conjugated; leaves morinda ... See more keywords
Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D
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DOI: 10.1016/j.ejmech.2018.11.068
Abstract: Following up the open initiative of anti-malarial drug discovery, a GlaxoSmithKline (GSK) phenotypic screening hit was developed to generate hydroxyethylamine based plasmepsin (Plm) inhibitors exhibiting growth inhibition of the malaria parasite Plasmodium falciparum at nanomolar… read more here.
Keywords: potent anti; malarial activity; anti malarial; plasmepsin ... See more keywords
Metacytofilin has potent anti-malarial activity.
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DOI: 10.1016/j.parint.2020.102267
Abstract: Metacytofilin (MCF) was isolated from the fungus Metarhizium sp. TA2759. Although MCF possesses anti-Toxoplasma activity, the effects of this compound against other parasites are unknown. Here, we evaluated the in vitro anti-malarial activity of MCF… read more here.
Keywords: malarial activity; anti malarial; mcf; ic50 ... See more keywords
Anti-malarial activity of traditional Kampo medicine Coptis rhizome extract and its major active compounds
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DOI: 10.1186/s12936-020-03273-x
Abstract: Herbal medicine has been a rich source of new drugs exemplified by quinine and artemisinin. In this study, a variety of Japanese traditional herbal medicine (‘Kampo’) were examined for their potential anti-malarial activities. A comprehensive… read more here.
Keywords: medicine; anti malarial; coptis rhizome; malarial activity ... See more keywords