Malat1 deficiency prevents neonatal heart regeneration by inducing cardiomyocyte binucleation
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.162124
Abstract: The adult mammalian heart has limited regenerative capacity, while the neonatal heart fully regenerates during the first week of life. Postnatal regeneration is mainly driven by proliferation of preexisting cardiomyocytes and supported by proregenerative macrophages… read more here.
Keywords: regeneration; malat1 deficiency; binucleation; heart ... See more keywords
Malat1 deficiency prevents hypoxia-induced lung dysfunction by protecting the access to alveoli
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.949378
Abstract: Hypoxia is common in lung diseases and a potent stimulator of the long non-coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1). Herein, we investigated the impact of Malat1 on hypoxia-induced lung dysfunction in mice. Malat1-deficient… read more here.
Keywords: lung; malat1 deficiency; malat1; hypoxia induced ... See more keywords