Enhancement of malate production through engineering of the periplasmic rTCA pathway in Escherichia coli
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26580
Abstract: The compartmentalization of enzymes into organelles is a promising strategy for limiting metabolic crosstalk and improving pathway efficiency; however, prokaryotes are unicellular organisms that lack membrane‐bound organelles. To mimic this natural compartmentalization, we present here… read more here.
Keywords: malate; rtca pathway; production; malate production ... See more keywords
Assessment of the sensitivity of 2 H MR spectroscopy measurements of [2,3-2 H2 ]fumarate metabolism for detecting tumor cell death.
Sign Up to like & getrecommendations! Published in 2023 at "NMR in biomedicine"
DOI: 10.1002/nbm.4965
Abstract: Imaging the metabolism of [2,3-2 H2 ]fumarate to produce malate can be used to detect tumor cell death post-treatment. Here we assess the sensitivity of the technique for detecting cell death by lowering the concentration… read more here.
Keywords: cell death; spectroscopy; fumarate; tumor ... See more keywords
Identification of major malate export systems in an engineered malate-producing Escherichia coli aided by substrate similarity search
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-10164-y
Abstract: Optimization of export mechanisms for valuable extracellular products is important for the development of efficient microbial production processes. Identification of the relevant export mechanism is the prerequisite step for product export optimization. In this work,… read more here.
Keywords: export; engineered malate; malate; producing escherichia ... See more keywords
MDH1 deficiency is a metabolic disorder of the malate–aspartate shuttle associated with early onset severe encephalopathy
Sign Up to like & getrecommendations! Published in 2019 at "Human Genetics"
DOI: 10.1007/s00439-019-02063-z
Abstract: The reversible oxidation of l-malate to oxaloacetate is catalyzed by NAD(H)-dependent malate dehydrogenase (MDH). MDH plays essential roles in the malate–aspartate shuttle and the tricarboxylic acid cycle. These metabolic processes are important in mitochondrial NADH… read more here.
Keywords: aspartate shuttle; malate; mdh1 deficiency; malate aspartate ... See more keywords
The Identity of “Chromium Malate”
Sign Up to like & getrecommendations! Published in 2017 at "Biological Trace Element Research"
DOI: 10.1007/s12011-017-1046-7
Abstract: Recently, several studies on the effects of a compound named “chromium malate,” with the proposed formula “Cr2malate3·xH2O” where x = 3.5 or 5, on the health of healthy and diabetic rats have appeared. However, the compound is… read more here.
Keywords: malate; identity chromium; chromium malate;
Molecular characterization of a cytosolic malate dehydrogenase gene(GhcMDH1) from cotton
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-017-6358-9
Abstract: Malate dehydrogenase(MDH) is a key enzyme that catalyzes the reversible oxidation of oxaloacetate to malate and plays an important role in the physiological processes of plant growth and development. However, cyto-solic malate dehydrogenase(cMDH), which is… read more here.
Keywords: cotton; malate; cytosolic malate; gene ... See more keywords
Malate and Aspartate Increase L-Arginine and Nitric Oxide and Attenuate Hypertension.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.04.071
Abstract: Fumarase catalyzes the interconversion of fumarate and L-malate in the tricarboxylic acid cycle. The Dahl salt-sensitive (SS) rat, a model of salt-sensitive hypertension, exhibits fumarase insufficiencies. To investigate the mechanism mediating the effect of fumarase-related… read more here.
Keywords: malate; arginine; hypertension malate; malate aspartate ... See more keywords
Co-overexpression of the malate dehydrogenase (Mdh) and the malic enzyme A (MaeA) in several Escherichia coli mutant backgrounds increases malate redirection towards hydrogen production
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Hydrogen Energy"
DOI: 10.1016/j.ijhydene.2021.02.100
Abstract: Abstract The combustion of fossil fuels is leading to global warming due to the emissions of greenhouse gases. Hydrogen (H2) is a clean and sustainable energy source and a promising alternative to fossil fuels. The… read more here.
Keywords: malic enzyme; malate dehydrogenase; overexpression malate; production ... See more keywords
Rewiring the reductive tricarboxylic acid pathway and L-malate transport pathway of Aspergillus oryzae for overproduction of L-malate.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2017.05.011
Abstract: Aspergillus oryzae finds wide application in the food, feed, and wine industries, and is an excellent cell factory platform for production of organic acids. In this work, we achieved the overproduction of L-malate by rewiring… read more here.
Keywords: transport pathway; malate; pathway; pathway malate ... See more keywords
Molecular cloning and functional characterization of the Aluminum-activated malate transporter gene MdALMT14
Sign Up to like & getrecommendations! Published in 2019 at "Scientia Horticulturae"
DOI: 10.1016/j.scienta.2018.08.045
Abstract: Abstract The salinity of soil severely restricts the rate of land use and crop productivity. Plants have developed complex mechanisms, including osmotic adjustment, to resist salt stress. Here, we report that the MdALMT14 gene in… read more here.
Keywords: transporter gene; gene; malate; activated malate ... See more keywords
Purification and Characterization of a Malate:Quinone Oxidoreductase from Pseudomonas taetrolens Capable of Producing Valuable Lactobionic Acid.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c04094
Abstract: In this study, we successfully purified a novel lactose-oxidizing enzyme in Pseudomonas taetrolens for the first time. The purified enzyme was identified as malate:quinone oxidoreductase (MQO, EC 1.1.5.4), which showed the malate-oxidizing activity converting malate… read more here.
Keywords: mqo; malate; quinone; pseudomonas taetrolens ... See more keywords