Molecular characterization of a cytosolic malate dehydrogenase gene(GhcMDH1) from cotton
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-017-6358-9
Abstract: Malate dehydrogenase(MDH) is a key enzyme that catalyzes the reversible oxidation of oxaloacetate to malate and plays an important role in the physiological processes of plant growth and development. However, cyto-solic malate dehydrogenase(cMDH), which is… read more here.
Keywords: cotton; malate; cytosolic malate; gene ... See more keywords
Pesticide interactions induce alterations in secondary structure of malate dehydrogenase to cause destability and cytotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2020.128074
Abstract: Environmental exposure to pesticides increases the risk of neurotoxicity and neurodegenerative diseases. The mechanism of pesticide-induced toxicity is attributed to the increased reactive oxygen species, mitochondrial dysfunction, inhibition of key cellular enzymes and accelerated pathogenic… read more here.
Keywords: secondary structure; pesticide; malate dehydrogenase; cytotoxicity ... See more keywords
Co-overexpression of the malate dehydrogenase (Mdh) and the malic enzyme A (MaeA) in several Escherichia coli mutant backgrounds increases malate redirection towards hydrogen production
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Hydrogen Energy"
DOI: 10.1016/j.ijhydene.2021.02.100
Abstract: Abstract The combustion of fossil fuels is leading to global warming due to the emissions of greenhouse gases. Hydrogen (H2) is a clean and sustainable energy source and a promising alternative to fossil fuels. The… read more here.
Keywords: malic enzyme; malate dehydrogenase; overexpression malate; production ... See more keywords
Th2-related immune responses by the Brucella abortus cellular antigens, malate dehydrogenase, elongation factor, and arginase.
Sign Up to like & getrecommendations! Published in 2017 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2017.06.019
Abstract: Brucellosis is an important zoonotic disease caused by Brucella species. The disease is difficult to control due to the intracellular survival of the bacterium and the lack of precise understanding of pathogenesis. Despite of continuous… read more here.
Keywords: brucella; th2 related; immune responses; elongation factor ... See more keywords
Methyl 3-(3-(4-(2,4,4-Trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b01231
Abstract: Previously, we reported a hypoxia-inducible factor (HIF)-1 inhibitor LW6 containing an (aryloxyacetylamino)benzoic acid moiety inhibits malate dehydrogenase 2 (MDH2) using a chemical biology approach. Structure-activity relationship studies on a series of (aryloxyacetylamino)benzoic acids identified selective… read more here.
Keywords: mdh2; inhibitor; malate dehydrogenase; cancer metabolism ... See more keywords
Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.36
Abstract: Increased glucose consumption is a hallmark of cancer cells. The increased consumption and subsequent metabolism of glucose during proliferation creates the need for a constant supply of NAD, a co-factor in glycolysis. Regeneration of the… read more here.
Keywords: glycolysis; cytosolic malate; proliferating cells; cancer ... See more keywords
Catalytic mechanism and kinetics of malate dehydrogenase
Sign Up to like & getrecommendations! Published in 2024 at "Essays in Biochemistry"
DOI: 10.1042/ebc20230086
Abstract: Abstract Malate dehydrogenase (MDH) is a ubiquitous and central enzyme in cellular metabolism, found in all kingdoms of life, where it plays vital roles in the cytoplasm and various organelles. It catalyzes the reversible NAD+-dependent… read more here.
Keywords: malate dehydrogenase; mechanism kinetics; kinetics malate; catalytic mechanism ... See more keywords
Uncovering malate dehydrogenase: structure, function and role in disease.
Sign Up to like & getrecommendations! Published in 2024 at "Essays in biochemistry"
DOI: 10.1042/ebc20240044
Abstract: Malate dehydrogenases (MDHs) have been extensively studied since the 1960s due to their key roles in carbon metabolism and pathways such as redox balance and lipid synthesis. Recently, there has been renewed interest in these… read more here.
Keywords: structure function; malate dehydrogenase; role;
Thermal Adaptation of Cytosolic Malate Dehydrogenase Revealed by Deep Learning and Coevolutionary Analysis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Chemical Theory and Computation"
DOI: 10.1101/2024.10.08.617074
Abstract: Protein evolution has produced enzymes that maintain stability and function across various thermal environments. While sequence variation, structural dynamics, and intermolecular interactions are known to influence an enzyme’s thermal adaptation, how these factors collectively govern… read more here.
Keywords: deep learning; adaptation; stability; cytosolic malate ... See more keywords
Plasmodium Parasite Malate-Quinone Oxidoreductase Functionally Complements a Yeast Deletion Mutant of Mitochondrial Malate Dehydrogenase
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00168-23
Abstract: We constructed a model organism to study the physiological role and function of P. falciparum malate-quinone oxidoreductase (PfMQO) in a yeast expression system. PfMQO is actively expressed in yeast mitochondria and functions in place of… read more here.
Keywords: malate quinone; mitochondrial malate; malate dehydrogenase; quinone oxidoreductase ... See more keywords
A Novel Role for Malate Dehydrogenase 1 in Acute Myeloid Leukemia Progression
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-125231
Abstract: The tumor suppressor role of the metabolic genes is rarely reported. Here, we report that malate dehydrogenase 1 (MDH1) acts as an anti-oncogene in acute myeloid leukemia (AML) progression. In a screen of various leukemia… read more here.
Keywords: mdh1; role; acute myeloid; progression ... See more keywords