Pharmacological Profiling of a Brugia malayi Muscarinic Acetylcholine Receptor as a Putative Antiparasitic Target
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01188-22
Abstract: The diversification of anthelmintic targets and mechanisms of action will help ensure the sustainable control of nematode infections in response to the growing threat of drug resistance. G protein-coupled receptors (GPCRs) are established drug targets… read more here.
Keywords: malayi; receptor; drug; medicine ... See more keywords
Localization and RNA Interference-Driven Inhibition of a Brugia malayi-Encoded Interleukin-5 Receptor Binding Protein
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Immunity"
DOI: 10.1128/iai.00317-21
Abstract: A molecule we termed Brugia malayi IL-5 receptor (IL-5R) binding protein (BmIL5Rbp; also known as Bm8757) was identified from B. malayi filarial worms and found to inhibit human interleukin-5 (IL-5) binding to its human receptor… read more here.
Keywords: malayi; bmil5rbp; microscopy; brugia malayi ... See more keywords
Molecular Characterization of a Reemergent Brugia malayi Parasite in Sri Lanka, Suggestive of a Novel Strain
Sign Up to like & getrecommendations! Published in 2021 at "BioMed Research International"
DOI: 10.1155/2021/9926101
Abstract: Sri Lanka achieved elimination status for lymphatic filariasis in 2016; still, the disease remains a potential public health issue. The present study is aimed at identifying a subperiodic Brugia sp. parasite which has reemerged in… read more here.
Keywords: brugia malayi; novel strain; malayi; sri lanka ... See more keywords
Reconstitution of an N-AChR from Brugia malayi, an evolved change in acetylcholine receptor accessory protein requirements in filarial parasites
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DOI: 10.1371/journal.ppat.1010962
Abstract: Neurotransmission is an important target for anthelmintic drugs, where receptor characteristics and response can be examined through reconstitution ex vivo in Xenopus laevis oocytes. The homomeric ACR-16 nicotine sensitive acetylcholine receptors (N-AChRs) of several helminth… read more here.
Keywords: malayi; accessory; brugia malayi; acetylcholine ... See more keywords
Study on vector mosquito of zoonotic Brugia malayi in Musi Rawas, South Sumatera, Indonesia
Sign Up to like & getrecommendations! Published in 2019 at "Veterinary World"
DOI: 10.14202/vetworld.2019.1729-1734
Abstract: Background and Aim: Studies to determine abundance, distribution, species composition, and mosquito interactions are very important in understanding the risk of disease transmission to implement appropriate mosquito management in endemic areas. Lymphatic filarial worms are… read more here.
Keywords: mosquito; musi rawas; rawas south; pauh village ... See more keywords
Fauna associated with Malayan filariasis transmission in Banyuasin, South Sumatra, Indonesia
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary World"
DOI: 10.14202/vetworld.2021.1954-1959
Abstract: Background and Aim: Brugia malayi is known to be zoonotically important because it can be transmitted from animals (mammals and primates) to humans or from humans to humans through mosquito vectors. This study was conducted… read more here.
Keywords: banyuasin; fauna associated; associated malayan; filariasis transmission ... See more keywords