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   Articles with "maldi msi" as a keyword



Using MALDI-TOF MS imaging and LC-HRMS for the investigation of the degradation of polycaprolactone diol exposed to different wastewater treatments

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recommendations! Published in 2017 at "Analytical and Bioanalytical Chemistry"

DOI: 10.1007/s00216-017-0371-1

Abstract: AbstractPolymers are used in high amounts in a wide range of applications from biomedicine to industry. Because of the growing awareness of the increasing amounts of plastic wastes in the aquatic environment during recent years,… read more here.

Keywords: degradation; wastewater; polycaprolactone diol; maldi msi ... See more keywords
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Recent developments of novel matrices and on-tissue chemical derivatization reagents for MALDI-MSI

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recommendations! Published in 2020 at "Analytical and Bioanalytical Chemistry"

DOI: 10.1007/s00216-020-03023-7

Abstract: Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a fast-growing technique for visualization of the spatial distribution of the small molecular and macromolecular biomolecules in tissue sections. Challenges in MALDI-MSI, such as poor sensitivity for… read more here.

Keywords: chemistry; tissue chemical; maldi msi; developments novel ... See more keywords

Molecular composition of fingermarks: Assessment of the intra- and inter-variability in a small group of donors using MALDI-MSI

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recommendations! Published in 2019 at "Forensic Chemistry"

DOI: 10.1016/j.forc.2018.12.002

Abstract: Abstract To date, a considerable amount of research has been devoted to the study of fingermark composition to serve many goals, such as the assessment of variability between donors, the impact of detection sequences, the… read more here.

Keywords: secretion residue; maldi msi; variability; composition ... See more keywords

Mapping of MeLiM melanoma combining ICP-MS and MALDI-MSI methods.

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recommendations! Published in 2022 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2022.01.139

Abstract: Here we developed a powerful tool for comprehensive data collection and mapping of molecular and elemental signatures in the Melanoma-bearing Libechov Minipig (MeLiM) model. The combination of different mass spectrometric methods allowed for detail investigation… read more here.

Keywords: melanoma combining; maldi msi; melim melanoma; mapping melim ... See more keywords

Visualizing the spatial distribution and alteration of metabolites in continuously cropped Salvia miltiorrhiza Bge using MALDI-MSI

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recommendations! Published in 2021 at "Journal of Pharmaceutical Analysis"

DOI: 10.1016/j.jpha.2021.09.011

Abstract: Abstract Salvia miltiorrhiza Bge (SMB) has long been used in traditional Chinese medicine to treat cardiovascular and cerebrovascular diseases. Growing clinical usage has led to a huge demand for artificial planting of SMB. Thus, continuous… read more here.

Keywords: continuously cropped; cropped smb; miltiorrhiza bge; metabolites continuously ... See more keywords

Improved Mass Calibration in MALDI MSI Using Neural Network-Based Recalibration

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recommendations! Published in 2024 at "Analytical Chemistry"

DOI: 10.1021/acs.analchem.4c00304

Abstract: Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is a powerful imaging method for generating molecular maps of biological samples and has numerous applications in biomedical research. A key challenge in MALDI MSI is to… read more here.

Keywords: msi; recalibration; neural network; mass ... See more keywords

Molecular Profiling of Glioblastoma Patient-Derived Single Cells Using Combined MALDI-MSI and MALDI-IHC

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recommendations! Published in 2025 at "Analytical Chemistry"

DOI: 10.1021/acs.analchem.4c03821

Abstract: In recent years, mass spectrometry-based imaging techniques have improved at unprecedented speeds, particularly in spatial resolution, and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) experiments can now routinely image molecular profiles of single cells… read more here.

Keywords: maldi; cell; maldi ihc; maldi msi ... See more keywords

Dual Mass Spectrometric Tissue Imaging of Nanocarrier Distributions and their Biochemical Effects.

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recommendations! Published in 2019 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.9b04398

Abstract: Nanomaterial-based drug delivery vehicles are able to deliver therapeutics in a controlled, targeted manner. Currently, however, there are limited analytical methods that can detect both nanomaterial distributions and their biochemical effects concurrently. In this study,… read more here.

Keywords: distributions biochemical; mass; tissue; biochemical effects ... See more keywords

MALDI MSI Protocol for Spatial Bottom-Up Proteomics at Single-Cell Resolution

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recommendations! Published in 2024 at "Journal of Proteome Research"

DOI: 10.1021/acs.jproteome.4c00528

Abstract: Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) started with spatial mapping of peptides and proteins. Since then, numerous bottom-up protocols have been developed. However, achievable spatial resolution and sample preparation with many wet steps… read more here.

Keywords: single cell; msi; resolution; bottom ... See more keywords

Spray-Based Application of Matrix to Agar-Based Microbial Samples for Reproducible Sample Adherence in MALDI MSI.

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recommendations! Published in 2022 at "Journal of the American Society for Mass Spectrometry"

DOI: 10.1021/jasms.1c00208

Abstract: Microbial mass spectrometry imaging (MSI) is a powerful tool used to generate biological hypotheses about the roles of metabolites in microbial competition based upon their two-dimensional spatial distribution. The most commonly used ionization method for… read more here.

Keywords: application; matrix; agar; msi ... See more keywords

A Matrix Sublimation Device with an Integrated Solvent Nebulizer for MALDI-MSI.

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recommendations! Published in 2021 at "Journal of the American Society for Mass Spectrometry"

DOI: 10.1021/jasms.1c00335

Abstract: The current matrix deposition methods in MALDI-mass spectrometry imaging (MALDI-MSI) face technical problems related to the inhomogeneous distribution of crystals and the low analyte extraction and cocrystallization efficiency. In this work, an integrated matrix sublimation… read more here.

Keywords: matrix sublimation; sublimation device; maldi msi; sublimation ... See more keywords