Glycan and Protein Analysis of Glycoengineered Bacterial E. coli Vaccines by MALDI-in-Source Decay FT-ICR Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2022 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.1c04690
Abstract: Bacterial glycoconjugate vaccines have a major role in preventing microbial infections. Immunogenic bacterial glycans, such as O-antigen polysaccharides, can be recombinantly expressed and combined with specific carrier proteins to produce effective vaccines. O-Antigen polysaccharides are… read more here.
Keywords: source decay; glycoconjugate vaccines; mass spectrometry; analysis ... See more keywords
Surface Effects of Iron Oxide Nanoparticles on the MALDI In-Source Decay Analysis of Glycans and Peptides
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DOI: 10.1021/acsanm.9b00988
Abstract: Inorganic nanoparticles as MALDI matrices have recently been explored to study the molecular mass determination and structural analysis of glycans and peptides. However, the specific factors contributing to the success of the analysis are not… read more here.
Keywords: analysis glycans; glycans peptides; source decay; nanoparticles maldi ... See more keywords
Improving spatial resolution of a LTQ Orbitrap MALDI source.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1021/jasms.0c00133
Abstract: Here we present a simple and cost effective procedure to improve the spatial resolution of the commercial MALDI source of a LTQ Orbitrap. Based in spatial filtering techniques, we demonstrate that, with minimal modifications of… read more here.
Keywords: resolution; spatial resolution; maldi source; ltq orbitrap ... See more keywords