Downregulation of leptin receptor and kisspeptin/GPR54 in the murine hypothalamus contributes to male hypogonadism caused by high-fat diet-induced obesity
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine"
DOI: 10.1007/s12020-018-1646-9
Abstract: PurposeObesity may lead to male hypogonadism, the underlying mechanism of which remains unclear. In the present study, we established a murine model of male hypogonadism caused by high-fat diet-induced obesity to verify the following hypotheses:… read more here.
Keywords: diet induced; male hypogonadism; induced obesity;
Epidemiology of Male Hypogonadism.
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DOI: 10.1016/j.ecl.2021.11.016
Abstract: The epidemiology of male hypogonadism has been understudied. Of the known causes of endogenous androgen deficiency, only Klinefelter syndrome is common with a likely population prevalence of greater than 5:10,000 men (possibly as high as… read more here.
Keywords: epidemiology; prevalence; androgen deficiency; male hypogonadism ... See more keywords
Hypogonadism: a neglected comorbidity in young and middle-aged HIV-positive men on effective combination antiretroviral therapy
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DOI: 10.1097/qad.0000000000003176
Abstract: Objective: Male hypogonadism is poorly characterized in young-to-middle-aged people with HIV (PWH). We used a reliable free testosterone assay to assess the prevalence and predictive factors for male hypogonadism in PWH on effective combined antiretroviral… read more here.
Keywords: hypogonadism; antiretroviral therapy; male hypogonadism; middle aged ... See more keywords
A new oral testosterone (TLANDO) treatment regimen without dose titration requirement for male hypogonadism
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DOI: 10.1111/andr.13153
Abstract: Male hypogonadism (testosterone level < 300 ng/dl) is a clinical syndrome that results from failure of the testis to produce physiological levels of testosterone. Most marketed testosterone replacement therapy products often require multiple dose adjustment… read more here.
Keywords: male hypogonadism; testosterone tlando; new oral; testosterone ... See more keywords
Expert Opinion on the Diagnosis and Management of Male Hypogonadism in India
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DOI: 10.1155/2023/4408697
Abstract: Male hypogonadism (MH) is a clinical and biochemical syndrome caused by inadequate synthesis of testosterone. Untreated MH can result in long-term effects, including metabolic, musculoskeletal, mood-related, and reproductive dysfunction. Among Indian men above 40 years of… read more here.
Keywords: expert opinion; hypogonadism; diagnosis; diagnosis management ... See more keywords
Editorial: Aging and male hypogonadism
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1207907
Abstract: COPYRIGHT © 2023 Xia, Yu, Liu, Chen, Ge and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums… read more here.
Keywords: editorial aging; male hypogonadism; aging male;
The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease
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DOI: 10.3390/antiox10111834
Abstract: Androgens have diverse functions in muscle physiology, lean body mass, the regulation of adipose tissue, bone density, neurocognitive regulation, and spermatogenesis, the male reproductive and sexual function. Male hypogonadism, characterized by reduced testosterone, is commonly… read more here.
Keywords: male hypogonadism; stress; age related; oxidative stress ... See more keywords
Plasma Metabolomics Profile of “Insulin Sensitive” Male Hypogonadism after Testosterone Replacement Therapy
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DOI: 10.3390/ijms23031916
Abstract: Male hypogonadism is a disorder characterized by low levels of testosterone, but patients can either show normal insulin (insulin-sensitive (IS)) or over time they can become insulin-resistant (IR). Since the two groups showed different altered… read more here.
Keywords: insulin sensitive; replacement therapy; male hypogonadism; testosterone replacement ... See more keywords
Adipose Tissue Dysfunction and Obesity-Related Male Hypogonadism
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DOI: 10.3390/ijms23158194
Abstract: Obesity is a chronic illness associated with several metabolic derangements and comorbidities (i.e., insulin resistance, leptin resistance, diabetes, etc.) and often leads to impaired testicular function and male subfertility. Several mechanisms may indeed negatively affect… read more here.
Keywords: male hypogonadism; adipose tissue; obesity; tissue dysfunction ... See more keywords
Secondary male hypogonadism: a prevalent but overlooked comorbidity of obesity
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DOI: 10.4103/aja.aja_44_18
Abstract: Male hypogonadism associated with obesity is a very prevalent condition and is increasing in parallel with the epidemic prevalence of obesity. Low testosterone levels promote higher fat mass with reduced lean mass. Male hypogonadism is… read more here.
Keywords: comorbidity obesity; obesity; prevalent; male hypogonadism ... See more keywords