Mode of action and human relevance assessment of male CD‐1 mouse renal adenocarcinoma associated with lifetime exposure to empagliflozin
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4329
Abstract: Inhibition of sodium‐glucose cotransporter‐2 (SGLT2) has been shown to be a safe and efficacious approach to support managing Type 2 diabetes. In the 2‐year carcinogenicity study with the SGLT2 inhibitor empagliflozin in CD‐1 mice, an… read more here.
Keywords: mouse renal; male mouse; mode action; mice ... See more keywords
Systematic evaluation of graphene quantum dot toxicity to male mouse sexual behaviors, reproductive and offspring health.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.12.001
Abstract: Graphene quantum dots (GQDs) have attracted considerable attention across multiple fields, particularly biomedical research. However, the effects of GQDs on reproductive and offspring health in mammals are unclear. Here, we show that GQD exposure via… read more here.
Keywords: graphene quantum; offspring health; male mouse; sexual behaviors ... See more keywords
GIPR gene expression in testis is mouse specific and can impact male mouse fertility
Sign Up to like & getrecommendations! Published in 2022 at "Andrology"
DOI: 10.1111/andr.13166
Abstract: Glucose‐dependent insulinotropic polypeptide receptor (Gipr) gene expression has been reported in mouse spermatids and Gipr knockout male mice have previously been reported to have decreased in vitro fertilization, although the role of Gipr signaling in… read more here.
Keywords: mouse fertility; mouse; gene expression; gipr gene ... See more keywords
Tac1 Signaling Is Required for Sexual Maturation and Responsiveness of GnRH Neurons to Kisspeptin in the Male Mouse
Sign Up to like & getrecommendations! Published in 2017 at "Endocrinology"
DOI: 10.1210/en.2016-1807
Abstract: The tachykinins substance P (SP) and neurokinin A (Tac1) have emerged as novel regulators of kisspeptin/GnRH release. Recently, we documented that SP modulates reproductive function in the female mouse. Here, we extended this characterization to… read more here.
Keywords: male mouse; gnrh neurons; receptor; gnrh ... See more keywords
The male mammary gland: a novel target of endocrine disrupting chemicals.
Sign Up to like & getrecommendations! Published in 2021 at "Reproduction"
DOI: 10.1530/rep-20-0615
Abstract: In the past several decades, the incidence of two male breast diseases, gynecomastia and male breast cancer, have increased in human populations. Whereas male breast cancer remains a rare disease, gynecomastia, a condition that arises… read more here.
Keywords: male breast; male; male mouse; male mammary ... See more keywords
Anatomical Transcriptome Atlas of the Male Mouse Reproductive System During Aging
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.782824
Abstract: The elderly males undergo degenerative fertility and testicular endocrine function that jeopardize the reproductive health and well-being. However, the mechanisms underlying reproductive aging are unclear. Here, we tried to address this by investigating the phenotypes… read more here.
Keywords: male mouse; mouse reproductive; system aging; male reproductive ... See more keywords
Peroxiredoxin 6 Peroxidase and Ca2+-Independent Phospholipase A2 Activities Are Essential to Support Male-Mouse Fertility
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11020226
Abstract: Human infertility is an important health problem that affects one in six couples worldwide. Half of these cases are due to male infertility. Oxidative stress is a common culprit of male infertility, promoting lipid peroxidation… read more here.
Keywords: male; mouse fertility; prdx6; peroxidase ... See more keywords