Comparative Pharmacokinetics, Safety, and Immunogenicity Study of the Prefilled Syringe and Lyophilized Formulation of a Recombinant Human Tumor Necrosis Factor‐α Receptor II:lgG Fc Fusion Protein in Healthy Chinese Male Subjects
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DOI: 10.1002/cpdd.1091
Abstract: This study aimed to compare the pharmacokinetics, safety, and immunogenicity of the prefilled syringe (PFS) with lyophilized (LYO) recombinant human tumor necrosis factor‐α receptor II:lgG Fc fusion protein (rhTNFR:Fc) in healthy Chinese male subjects. A… read more here.
Keywords: safety; chinese male; healthy chinese; immunogenicity ... See more keywords
A phase I study of the effect of repeated oral doses of pantoprazole on the pharmacokinetics of a single dose of fedratinib in healthy male subjects
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-020-04074-4
Abstract: Purpose Fedratinib, an oral, selective Janus kinase 2 inhibitor with activity against both wild-type and mutant Janus kinase 2, has pH-dependent solubility, with free solubility at pH 1. Concomitant administration of drugs that reduce gastric… read more here.
Keywords: healthy male; study; male subjects; doses pantoprazole ... See more keywords
Sexual dimorphism of detrusor function demonstrated by urodynamic studies in rhesus macaques
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DOI: 10.1038/s41598-020-73016-0
Abstract: The lower urinary tract (LUT) and micturition reflexes are sexually dimorphic across mammals. Sex as a biological variable is also of critical importance for the development and translation of new medical treatments and therapeutics interventions… read more here.
Keywords: detrusor function; male subjects; rhesus macaques; function ... See more keywords
Pharmacokinetics and Pharmacodynamics of Tofogliflozin (a Selective SGLT2 Inhibitor) in Healthy Male Subjects.
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DOI: 10.1055/s-0043-104779
Abstract: Tofogliflozin is a selective oral inhibitor of sodium-glucose co-transporter 2 for treatment of type 2 diabetes mellitus. The pharmacokinetics, pharmacodynamics, and safety of tofogliflozin were investigated in healthy male subjects. Three studies were conducted: single-ascending… read more here.
Keywords: healthy male; inhibitor; tofogliflozin; male subjects ... See more keywords
A phase I study comparing the pharmacokinetics of the biosimilar (RD12014) with liraglutide (Victoza) in healthy Chinese male subjects
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DOI: 10.1111/cts.13374
Abstract: This study aimed to evaluate the pharmacokinetics (PKs), safety, and immunogenicity of the biosimilar (RD12014) compared to reference liraglutide (Victoza) in healthy Chinese male subjects, so as to provide the basis for the similarity evaluation… read more here.
Keywords: chinese male; healthy chinese; victoza healthy; male subjects ... See more keywords
Lifestyle and Occupational Stress: A Potential Risk Factor for Obstructive Sleep Apnea in Nonobese Male Subjects
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Prosthodontics"
DOI: 10.1111/jopr.12627
Abstract: PURPOSE To record the incidence of obstructive sleep apnea (OSA) in nonobese male subjects and investigate the coexistence of lifestyle stress, sleep deprivation, and upper airway inflammation. MATERIALS AND METHODS 552 patients were assessed during… read more here.
Keywords: upper airway; male subjects; stress; obstructive sleep ... See more keywords
Pharmacokinetic and pharmacodynamic interaction between ezetimibe and rosuvastatin in healthy male subjects
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DOI: 10.2147/dddt.s146863
Abstract: Background and objective Rosuvastatin and ezetimibe are commonly applied in lipid-lowering pharmacotherapy. However, the pharmacokinetic (PK) interaction was not clear by the coadministration of rosuvastatin and ezetimibe. This study investigated the pharmacodynamic (PD) and PK… read more here.
Keywords: healthy male; rosuvastatin ezetimibe; ezetimibe; male subjects ... See more keywords
The optimal pulse pressures for healthy adults with different ages and sexes correlate with cardiovascular health metrics
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DOI: 10.3389/fcvm.2022.930443
Abstract: Background Pulse pressure (PP) may play a role in the development of cardiovascular disease, and the optimal PP for different ages and sexes is unknown. In a prospective cohort, we studied subjects with favorable cardiovascular… read more here.
Keywords: ages sexes; health; age; different ages ... See more keywords
A Randomized Phase 1 Pharmacokinetic Study Comparing the Potential Biosimilar LRG201902 With Liraglutide (Victoza®) in Healthy Male Subjects
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DOI: 10.3389/fphar.2020.610880
Abstract: Objective: Pharmacokinetic (PK) similarity between biosimilar candidate LRG201902 and European Union-sourced liraglutide reference product (Victoza®) was evaluated. Safety and immunogenicity were also assessed. Methods: This single-dose, randomized, open-label, 2-period crossover study (CTR20192342) was conducted in… read more here.
Keywords: auc0 auc0; lrg201902; study; male subjects ... See more keywords
A Randomized, Double-Blind, Single-Dose Study Comparing the Biosimilarity of HOT-1010 With Bevacizumab (Avastin®) in Chinese Healthy Male Subjects
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DOI: 10.3389/fphar.2021.694375
Abstract: Objective: This study was conducted to compare the pharmacokinetics, safety and immunogenicity of HOT-1010 with bevacizumab (Avastin®) in Chinese healthy male subjects. Methods: A single-center, randomized, double-blind, single-dose, parallel trial was performed in 84 Chinese… read more here.
Keywords: healthy male; hot 1010; chinese healthy; bevacizumab avastin ... See more keywords
A single-dose, randomized, open-labeled, parallel-group study comparing the pharmacokinetics, pharmacodynamics and safety of leuprolide acetate microspheres 3.75 mg and Enantone® 3.75 mg in healthy male subjects
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DOI: 10.3389/fphar.2022.946505
Abstract: Leuprolide acetate microspheres developed by Shanghai Livzon Pharmaceutical Co., Ltd. (T) have been marketed in China for more than 10 years, benefiting a large number of patients, and will continue to play an important role… read more here.
Keywords: acetate microspheres; safety; leuprolide acetate; single dose ... See more keywords