Effect of Food on the Pharmacokinetics and Pharmacodynamics of a Single Oral Dose of SHR4640, a Selective Urate Transporter 1 Inhibitor, in Healthy Chinese Male Volunteers
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DOI: 10.1002/cpdd.1191
Abstract: SHR4640, also named as ruzinurad, is a selective human urate transporter 1 (URAT1) inhibitor developed for the treatment of hyperuricemia and gout. This study evaluated the high‐fat, high‐calorie food effect on the pharmacokinetics and pharmacodynamics… read more here.
Keywords: food; dose shr4640; healthy chinese; male volunteers ... See more keywords
Pharmacokinetics of intravenous pan-class I phosphatidylinositol 3-kinase (PI3K) inhibitor [14C]copanlisib (BAY 80-6946) in a mass balance study in healthy male volunteers
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DOI: 10.1007/s00280-017-3383-9
Abstract: PurposeTo determine the pharmacokinetics of radiolabeled copanlisib (BAY 80-6946) in healthy male volunteers and to investigate the disposition and biotransformation of copanlisib.MethodsA single dose of 12 mg copanlisib containing 2.76 MBq [14C]copanlisib was administered as a 1-h… read more here.
Keywords: healthy male; copanlisib; male volunteers; 14c copanlisib ... See more keywords
Pharmacokinetics and Pharmacodynamics of Remimazolam (CNS 7056) after Continuous Infusion in Healthy Male Volunteers
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DOI: 10.1097/aln.0000000000003103
Abstract: Background: Remimazolam (CNS 7056) is a new ultra–short-acting benzodiazepine for intravenous sedation and anesthesia. Its pharmacokinetics and pharmacodynamics have been reported for bolus administration. This study aimed to investigate the pharmacokinetics and pharmacodynamics of remimazolam… read more here.
Keywords: male volunteers; min min; infusion; remimazolam ... See more keywords
KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers
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DOI: 10.1186/s13023-017-0715-0
Abstract: BackgroundMitochondrial disorders are a clinically, biochemically and genetically heterogeneous group of multi-system diseases, with an unmet medical need for treatment. KH176 is an orally bio-available small molecule under development for the treatment of mitochondrial(−related) diseases.… read more here.
Keywords: healthy male; clinical trial; trial; male volunteers ... See more keywords
141-LB: Engineered Silica Particles Work as a Molecular Sieve and Reduce Metabolic Risk Factors in Obese Male Volunteers
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DOI: 10.2337/db19-141-lb
Abstract: Mesoporous silica particles (MSPs) are thermally and chemically stable porous materials composed exclusively of silicon dioxide. Here we report the results of a First-in-Man clinical trial evaluating engineered MSPs with controlled surface area, pore volume,… read more here.
Keywords: male volunteers; molecular sieve; risk factors; sigrid therapeutics ... See more keywords
Efficacy of FurosapTM, a novel Trigonella foenum-graecum seed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers
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DOI: 10.7150/ijms.17256
Abstract: Background: Dietary fiber rich fenugreek (Trigonella foenum-graecum) seeds have exhibited cardioprotective, hypolipidemic and other health benefits. Furosap (FS), an innovative, patented, 20% protodioscin-enriched extract was developed in our laboratory from fenugreek seeds. This study examined… read more here.
Keywords: seed; male volunteers; study; testosterone ... See more keywords