Obese male Zucker rats exhibit dendritic remodeling in neurons of the hippocampal trisynaptic circuit as well as spatial memory deficits
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DOI: 10.1002/hipo.23473
Abstract: Obesity is characterized by excessive fat accumulation. The Zucker rat displays genetic obesity due to a mutation in the leptin receptor gene; this model is of great interest because of its similarity to human obesity.… read more here.
Keywords: zucker; spatial memory; obese male; zucker rats ... See more keywords
The Treatment With the SGLT2 Inhibitor Empagliflozin Modifies the Hepatic Metabolome of Male Zucker Diabetic Fatty Rats Towards a Protective Profile
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DOI: 10.3389/fphar.2022.827033
Abstract: The EMPA-REG OUTCOME (Empagliflozin, Cardiovascular Outcome Event Trial in patients with Type 2 Diabetes Mellitus (T2DM)) trial evidenced the potential of sodium-glucose cotransporter 2 (SGLT2) inhibitors for the treatment of patients with diabetes and cardiovascular… read more here.
Keywords: male zucker; empagliflozin; zucker diabetic; inhibitor empagliflozin ... See more keywords