Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors.
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DOI: 10.4155/fmc-2017-0074
Abstract: AIM DNA methyltransferases (DNMTs) are important drug targets for epigenetic therapy of cancer. Nowadays, non-nucleoside DNMT inhibitors are in development to address high toxicity of nucleoside analogs. However, these compounds still have low activity in… read more here.
Keywords: maleimide derivatives; inhibition studies; dna methyltransferases; non nucleoside ... See more keywords