Malic Enzyme 1 as a Novel Anti‐Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205436
Abstract: Ferroptosis has been linked to the pathogenesis of hepatic injury induced by ischemia/reperfusion (I/R). However, the mechanistic basis remains unclear. In this study, by using a mouse model of hepatic I/R injury, it is observed… read more here.
Keywords: malic enzyme; me1; injury; ischemia reperfusion ... See more keywords
Malic Enzyme 1 as a Novel Anti‐Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury (Adv. Sci. 13/2023)
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202370079
Abstract: Malic Enzyme 1 In article number 2205436, Xuexian Fang, Fudi Wang, and co‐workers discover Malic Enzyme 1 (ME1) as a novel ferroptosis inhibitory gene, which protects the liver function against ischemia/reperfusion (I/R) injury. The design… read more here.
Keywords: reperfusion injury; ischemia reperfusion; injury; malic enzyme ... See more keywords
Malic enzyme 2 as a potential therapeutic drug target for cancer
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1930
Abstract: Reprogrammed metabolic profile is a biochemical fingerprint of cancerous cells, which represents one of the “hallmarks of cancer.” The aberrant expression pattern of enzymatic machineries orchestrates metabolic activities into a platform that ultimately promotes cellular… read more here.
Keywords: enzyme potential; malic enzyme; target; therapeutic drug ... See more keywords
A novel malic enzyme gene, Mime2, from Mortierella isabellina M6-22 contributes to lipid accumulation
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology Letters"
DOI: 10.1007/s10529-018-2560-1
Abstract: ObjectiveThis study was aimed at cloning and characterizing a novel malic enzyme (ME) gene of Mortierella isabellina M6-22 and identifying its relation with lipid accumulation.MethodsMime2 was cloned from strain M6-22. Plasmid pET32aMIME2 was constructed to… read more here.
Keywords: novel malic; lipid accumulation; malic enzyme; mime2 ... See more keywords
Malic Enzyme Couples Mitochondria with Aerobic Glycolysis in Osteoblasts
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DOI: 10.1016/j.celrep.2020.108108
Abstract: SUMMARY The metabolic program of osteoblasts, the chief bone-making cells, remains incompletely understood. Here in murine calvarial cells, we establish that osteoblast differentiation under aerobic conditions is coupled with a marked increase in glucose consumption… read more here.
Keywords: couples mitochondria; aerobic glycolysis; malic enzyme; glycolysis osteoblasts ... See more keywords
Co-overexpression of the malate dehydrogenase (Mdh) and the malic enzyme A (MaeA) in several Escherichia coli mutant backgrounds increases malate redirection towards hydrogen production
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Hydrogen Energy"
DOI: 10.1016/j.ijhydene.2021.02.100
Abstract: Abstract The combustion of fossil fuels is leading to global warming due to the emissions of greenhouse gases. Hydrogen (H2) is a clean and sustainable energy source and a promising alternative to fossil fuels. The… read more here.
Keywords: malic enzyme; malate dehydrogenase; overexpression malate; production ... See more keywords
In the Quest for Potent and Selective Malic Enzyme 3 Inhibitors for the Treatment of Pancreatic Ductal Adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00369
Abstract: The genome of pancreatic ductal adenocarcinoma (PDAC) is associated with frequent deletion of the tumor suppressor gene SMAD family member 4 (SMAD4) with collateral deletion of its chromosomal neighbor malic enzyme 2 (ME2). In SMAD4… read more here.
Keywords: malic enzyme; me2; ductal adenocarcinoma; enzyme ... See more keywords
Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature21052
Abstract: The genome of pancreatic ductal adenocarcinoma (PDAC) frequently contains deletions of tumour suppressor gene loci, most notably SMAD4, which is homozygously deleted in nearly one-third of cases. As loss of neighbouring housekeeping genes can confer… read more here.
Keywords: cancer; collateral lethality; malic enzyme; mitochondrial malic ... See more keywords
Regulation at Drosophila's Malic Enzyme highlights the complexity of transvection and its sensitivity to genetic background.
Sign Up to like & getrecommendations! Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyac181
Abstract: Transvection, a type of trans-regulation of gene expression in which regulatory elements on one chromosome influence elements on a paired homologous chromosome, is itself a complex biological phenotype subject to modification by genetic background effects.… read more here.
Keywords: malic enzyme; variation; genetic background; transvection ... See more keywords
Malic enzyme 2 as a therapeutic target for cancer: comments on ‘Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate’
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjac024
Abstract: In mammalian cells, there are three isoforms of malic enzymes (MEs): a cytosolic nicotinamide adenine dinucleotide phosphate + (NADP + )-dependent isoform (ME1), a mitochondrial NAD(P) + -dependent isoform (ME2), and a mitochondrial NADP +… read more here.
Keywords: therapeutic target; malic enzyme; dependent isoform; enzyme therapeutic ... See more keywords
NADP-MALIC ENZYME 1 Affects Germination after Seed Storage in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2019 at "Plant and Cell Physiology"
DOI: 10.1093/pcp/pcy213
Abstract: Aging decreases the quality of seeds and results in agricultural and economic losses. The damage that occurs at the biochemical level can alter the seed physiological status. Although loss of viability has been investigated frequently,… read more here.
Keywords: seed; arabidopsis thaliana; malic enzyme; nadp me1 ... See more keywords