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   Articles with "malignant cell" as a keyword



No association of malignant B‐cell non‐Hodgkin lymphomas with ipsilateral SARS‐CoV‐2 vaccination

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recommendations! Published in 2023 at "Cancer Medicine"

DOI: 10.1002/cam4.5687

Abstract: SARS‐CoV‐2 vaccines cause acute ipsilateral lymph node swelling in an important proportion of vaccines. Thus far, no malignant lymphadenopathies have been reported in temporal context to vaccination in the ipsilateral draining lymph node areas. read more here.

Keywords: non hodgkin; vaccination; association malignant; cell non ... See more keywords

ETMR-17. SINGLE-CELL TRANSCRIPTOME ANALYSIS OF ETMR PATIENT SAMPLES

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recommendations! Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.220

Abstract: Abstract Brain tumors are comprised of cells with heterogeneous genetic and transcriptional states, resulting in substantial phenotypic diversity. This diversity is particularly evident in embryonal tumor with multilayered rosettes (ETMR), which shows a striking bi-phasic… read more here.

Keywords: single cell; etmr; cell transcriptome; malignant cell ... See more keywords

Single nucleus transcriptomics, pharmacokinetics, and pharmacodynamics of CDK4/6 and mTOR inhibition in a phase 0/1 trial of recurrent high-grade glioma.

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recommendations! Published in 2025 at "Neuro-oncology"

DOI: 10.1093/neuonc/noaf257

Abstract: BACKGROUND Outcomes for adult patients with high-grade glioma (HGG) remain poor, necessitating new treatment strategies. Key challenges include poor drug penetration in the brain and malignant cell state plasticity. Phase 0 studies identify agents that… read more here.

Keywords: malignant cell; trial; pharmacokinetics pharmacodynamics; cell ... See more keywords

Infection with Neoehrlichia mikurensis promotes the development of malignant B‐cell lymphomas

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recommendations! Published in 2023 at "British Journal of Haematology"

DOI: 10.1111/bjh.18652

Abstract: The tick‐borne pathogen Neoehrlichia (N.) mikurensis is implicated in persistent infection of the vascular endothelium. B cells are crucial for the host defence to this infection. Chronic stimulation of B cells may result in B‐cell… read more here.

Keywords: cell; development malignant; infection; mikurensis ... See more keywords

Paired Single Cell RNA and TCR Sequencing Analysis Following PD-L1 Blockade in Cutaneous T-Cell Lymphoma

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recommendations! Published in 2020 at "Blood"

DOI: 10.1182/blood-2020-139992

Abstract: Introduction: T cell exhaustion is a hallmark of CTCL and alterations in mRNA profiles correlate with immune checkpoint expression, with potential clinical relevance (Querfeld et al. 2018). There is no immunophenotypic marker that can distinguish… read more here.

Keywords: analysis; malignant cell; expression; cell ... See more keywords

Single-Cell Atlas of Diffuse Large B-Cell Lymphoma Reveals Integrated Malignant B Cell and Tumor Microenvironment Characteristics Associated with Clinical Response

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-209815

Abstract: Background: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive B-cell lymphoma with high clinical and biological heterogeneity. Despite current effective immunochemotherapy, up to 40% of patients do not respond or develop refractory disease.… read more here.

Keywords: malignant cell; cell atlas; cell lymphoma; single cell ... See more keywords
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An image-based flow cytometric approach to the assessment of the nucleus-to-cytoplasm ratio

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recommendations! Published in 2021 at "PLoS ONE"

DOI: 10.1371/journal.pone.0253439

Abstract: The nucleus-to-cytoplasm ratio (N:C) can be used as one metric in histology for grading certain types of tumor malignancy. Current N:C assessment techniques are time-consuming and low throughput. Thus, in high-throughput clinical contexts, there is… read more here.

Keywords: cytoplasm ratio; ratio; malignant cell; cancer ... See more keywords

Multi-omics integration reveals a six-malignant cell maker gene signature for predicting prognosis in high-risk neuroblastoma

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recommendations! Published in 2022 at "Frontiers in Neuroinformatics"

DOI: 10.3389/fninf.2022.1034793

Abstract: Background Neuroblastoma is the most common extracranial solid tumor of childhood, arising from the sympathetic nervous system. High-risk neuroblastoma (HRNB) remains a major therapeutic challenge with low survival rates despite the intensification of therapy. This… read more here.

Keywords: malignant cell; cell; high risk; hrnb patients ... See more keywords

The Road to Malignant Cell Transformation after Particulate Matter Exposure: From Oxidative Stress to Genotoxicity

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24021782

Abstract: In cells, oxidative stress is an imbalance between the production/accumulation of oxidants and the ability of the antioxidant system to detoxify these reactive products. Reactive oxygen species (ROS), cause multiple cellular damages through their interaction… read more here.

Keywords: stress; oxidative stress; particulate matter; malignant cell ... See more keywords