Radiomics analysis of amide proton transfer‐weighted and structural MR images for treatment response assessment in malignant gliomas
Sign Up to like & getrecommendations! Published in 2022 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4824
Abstract: The purpose of this study was to evaluate the value of amide proton transfer‐weighted (APTw) MRI radiomic features for the differentiation of tumor recurrence from treatment effect in malignant gliomas. Eighty‐six patients who had suspected… read more here.
Keywords: analysis; amide proton; structural images; treatment ... See more keywords
Adjuvant chemotherapy after severe myelotoxicity during chemoradiation phase in malignant gliomas. Is it feasibile? Results from AINO study (Italian Association for Neuro-Oncology)
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurology"
DOI: 10.1007/s00415-021-10438-4
Abstract: Malignant gliomas (MG) are aggressive brain tumours in adults. The standard of care is concurrent radiation plus temozolomide (TMZ) [chemo-radiotherapy (CRT)] followed by TMZ maintenance up to 6 months. TMZ is considered to have a… read more here.
Keywords: adjuvant chemotherapy; malignant gliomas; neuro oncology; myelotoxicity ... See more keywords
A Second Course of Radiotherapy in Patients with Recurrent Malignant Gliomas: Clinical Data on Re-irradiation, Prognostic Factors, and Usefulness of Digital Biomarkers
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DOI: 10.1007/s11864-019-0673-y
Abstract: The treatment of malignant gliomas has undergone a significant intensification during the past decade, and the interdisciplinary treatment team has learned that all treatment opportunities, including surgery and radiotherapy (RT), also have a central role… read more here.
Keywords: irradiation; second course; malignant gliomas; treatment ... See more keywords
Astrocyte elevated gene-1 as a novel therapeutic target in malignant gliomas and its interactions with oncogenes and tumor suppressor genes
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DOI: 10.1016/j.brainres.2020.147034
Abstract: Astrocyte elevated gene-1 (AEG-1) is an oncogene and a critical signaling molecule that has a wide variety of interactions with other oncogenes and tumor suppressor genes, leading to increasing malignant properties of malignant gliomas, such… read more here.
Keywords: interactions oncogenes; gliomas; malignant gliomas; oncogenes tumor ... See more keywords
Chemotherapy toxicities and geriatric syndromes in older patients with malignant gliomas.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of geriatric oncology"
DOI: 10.1016/j.jgo.2020.07.001
Abstract: OBJECTIVE To describe treatment toxicities and polypharmacy in older patients with malignant gliomas (MG). BACKGROUND Advanced age in cancer patients is associated with increased treatment-related toxicities, acute care utilization and functional decline. Most patients with… read more here.
Keywords: geriatric syndromes; malignant gliomas; age; treatment ... See more keywords
Correlations of MGMT genetic polymorphisms with temozolomide resistance and prognosis of patients with malignant gliomas: a population-based study in China
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DOI: 10.1038/cgt.2017.7
Abstract: This study aims to investigate the associations of O6-methylguanine-DNA methyltransferase (MGMT) genetic polymorphisms (Leu84Phe and Ile143Val) with temozolomide (TMZ) resistance and prognosis of patients with malignant gliomas. A total of 212 patients diagnosed with malignant… read more here.
Keywords: malignant gliomas; patients malignant; study; resistance ... See more keywords
Characterizing Distress and Identifying Modifiable Intervention Targets for Family Caregivers of Patients with Malignant Gliomas.
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DOI: 10.1089/jpm.2021.0534
Abstract: Background: Individuals caring for patients with malignant gliomas experience high rates of anxiety; however, an in-depth understanding of their distress and evidence-based interventions to target their needs are lacking. Objective: We conducted semistructured interviews with… read more here.
Keywords: distress; caregivers patients; anxiety; patients malignant ... See more keywords
DDRE-17. INITIAL CLINICAL EXPERIENCE USING OSIMERTINIB IN PATIENTS WITH RECURRENT MALIGNANT GLIOMAS WITH EGFR ALTERATIONS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.262
Abstract: EGFR alterations are commonly observed in malignant gliomas (MG), especially glioblastomas, making this pathway an appealing therapeutic target. Unlike other EGFR tyrosine kinase inhibitors (TKIs), osimertinib (osi), a third-generation, irreversible EGFR-TKI commonly used to treat… read more here.
Keywords: egfr; malignant gliomas; egfr alterations; patients recurrent ... See more keywords
MEOX2 homeobox gene promotes growth of malignant gliomas.
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DOI: 10.1093/neuonc/noac110
Abstract: BACKGROUND Glioblastoma (GBM) is an aggressive tumor that frequently exhibits gain of chromosome 7, loss of chromosome 10 and aberrantly activated receptor tyrosine kinase signaling pathways. Previously, we identified Mesenchyme Homeobox 2 (MEOX2), a gene… read more here.
Keywords: gbm; growth; homeobox; meox2 ... See more keywords
Polio Virotherapy Targets the Malignant Glioma Myeloid Infiltrate with Diffuse Microglia Activation Engulfing the CNS.
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DOI: 10.1093/neuonc/noad052
Abstract: BACKGROUND Malignant gliomas commandeer dense inflammatory infiltrates with glioma-associated macrophages and microglia (GAMM) promoting immune suppression, -evasion, and tumor progression. Like all cells in the mononuclear phagocytic system, GAMM constitutively express the poliovirus receptor, CD155.… read more here.
Keywords: polio virotherapy; infiltrate; microglia activation; activation ... See more keywords
Abstract 5103: Development of MJ-66 as a novel anticancer agent for the treatment of malignant gliomas
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DOI: 10.1158/1538-7445.am2017-5103
Abstract: Malignant glioma is the most common aggressive adult primary tumor of the central nervous system. Treatments of malignant gliomas include surgery, radiotherapy and adjuvant temozolomide (TMZ) chemotherapy. However, inherent- and acquired resistance to TMZ present… read more here.
Keywords: agent; malignant gliomas; treatment; treatment malignant ... See more keywords