MLLT10 in benign and malignant hematopoiesis.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental hematology"
DOI: 10.1016/j.exphem.2020.06.002
Abstract: Non-random chromosomal translocations involving the putative transcription factor, Mixed Lineage Leukemia Translocated to, 10 (MLLT10, also known as AF10) are commonly observed in both acute myeloid and lymphoid leukemias, and are indicative of a poor… read more here.
Keywords: mllt10 benign; hematopoiesis; malignant hematopoiesis; benign malignant ... See more keywords
The role of m6A mRNA modification in normal and malignant hematopoiesis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiad061
Abstract: Hematopoiesis is a highly orchestrated biological process sustaining the supply of leukocytes involved in the maintenance of immunity, O2 and CO2 exchange, and wound healing throughout the life-time of an animal including human. During early… read more here.
Keywords: modification; malignant hematopoiesis; role m6a; mrna modification ... See more keywords
Nestin Regulates Keap1-Nrf2-HO-1-Mediated Antioxidant Responses during Stress and Malignant Hematopoiesis
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/1706585
Abstract: Objective To investigate the role of nestin in regulating Keap1-nuclear factor erythroid-2-related factor 2 (Nrf2)-heme oxygenase-1-(HO-1-) mediated antioxidant responses in stress and malignant hematopoiesis. Methods The mRNA of peripheral blood mononuclear cells was extracted from… read more here.
Keywords: antioxidant responses; keap1 nrf2; stress malignant; mediated antioxidant ... See more keywords
The Opportunity of Proteomics to Advance the Understanding of Intra- and Extracellular Regulation of Malignant Hematopoiesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.824098
Abstract: Fetal and adult hematopoiesis are regulated by largely distinct sets of cell-intrinsic gene regulatory networks as well as extracellular cues in their respective microenvironment. These ontogeny-specific programs drive hematopoietic stem and progenitor cells (HSPCs) in… read more here.
Keywords: opportunity proteomics; adult; intra extracellular; hematopoiesis ... See more keywords
The Role of DOT1L in Normal and Malignant Hematopoiesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.917125
Abstract: Disruptor of telomeric silencing 1 (DOT1) was first identified in yeast (DOT1p) and is the sole methyltransferase responsible for histone three lysine 79 (H3K79) mono-, di-, and tri-methylation. Mammalian DOT1 (DOT1-like protein or DOT1L) has… read more here.
Keywords: dot1l function; dot1l normal; dot1l; hematopoiesis ... See more keywords
Autophagy and Metabolism in Normal and Malignant Hematopoiesis
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22168540
Abstract: The hematopoietic system relies on regulation of both metabolism and autophagy to maintain its homeostasis, ensuring the self-renewal and multipotent differentiation potential of hematopoietic stem cells (HSCs). HSCs display a distinct metabolic profile from that… read more here.
Keywords: autophagy metabolism; metabolism; normal malignant; differentiation ... See more keywords