Analysis of Human Leukocyte Antigen DR Alleles, Immune-Related Adverse Events, and Survival Associated With Immune Checkpoint Inhibitor Use Among Patients With Advanced Malignant Melanoma
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.46400
Abstract: Key Points Question What is the association between immune-related adverse events (irAEs) and survival after immune checkpoint inhibitor (ICI) therapy initiation and human leukocyte antigen genes in patients with advanced malignant melanoma? Findings In this… read more here.
Keywords: advanced malignant; patients advanced; immune related; related adverse ... See more keywords
Overexpression of long non‐coding RNA NORAD promotes invasion and migration in malignant melanoma via regulating the MIR‐205‐EGLN2 pathway
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DOI: 10.1002/cam4.2046
Abstract: Growing evidence suggests that long non‐coding RNAs NORAD and miR‐205 play a significant role in regulating cancer progression and metastasis. In this study, high expression of NORAD was firstly observed in melanoma tissues and human… read more here.
Keywords: melanoma; mir 205; 205 egln2; norad mir ... See more keywords
The spectrum of malignant melanoma on cytology: A tertiary care center study
Sign Up to like & getrecommendations! Published in 2019 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.24265
Abstract: Malignant melanoma accounts for around 3% of all malignancies. Fine‐needle aspiration cytology (FNAC) is a convenient diagnostic procedure for the diagnosis of melanoma and its metastases. read more here.
Keywords: melanoma; melanoma cytology; cytology tertiary; malignant melanoma ... See more keywords
Mid‐term trends and recent birth‐cohort‐dependent changes in incidence rates of cutaneous malignant melanoma in Italy
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Cancer"
DOI: 10.1002/ijc.33259
Abstract: In Oceania, North America and north‐western Europe, after decades of increase, cutaneous malignant melanoma (CMM) rates began to stabilise or decline before 2000. Anecdotal evidence suggests that the reversal of the incidence trend is extending… read more here.
Keywords: incidence; cohort dependent; cohort; cutaneous malignant ... See more keywords
Mefloquine induces ER stress and apoptosis in BRAFi‐resistant A375‐BRAFV600E/NRASQ61K malignant melanoma cells targeting intracranial tumors in a bioluminescent murine model
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23407
Abstract: Molecularly targeted therapeutics have revolutionized the treatment of BRAFV600E‐driven malignant melanoma, but the rapid development of resistance to BRAF kinase inhibitors (BRAFi) presents a significant obstacle. The use of clinical antimalarials for the investigational treatment… read more here.
Keywords: melanoma; brafv600e; brafv600e nrasq61k; a375 brafv600e ... See more keywords
Poly(N-phenylglycine)-Based Nanoparticles as Highly Effective and Targeted Near-Infrared Photothermal Therapy/Photodynamic Therapeutic Agents for Malignant Melanoma.
Sign Up to like & getrecommendations! Published in 2017 at "Small"
DOI: 10.1002/smll.201602496
Abstract: Malignant melanoma is a highly aggressive tumor resistant to chemotherapy. Therefore, the development of new highly effective therapeutic agents for the treatment of malignant melanoma is highly desirable. In this study, a new class of… read more here.
Keywords: melanoma; phenylglycine; highly effective; malignant melanoma ... See more keywords
KCNQ1OT1 sponges miR‐34a to promote malignant progression of malignant melanoma via upregulation of the STAT3/PD‐L1 axis
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DOI: 10.1002/tox.23687
Abstract: Malignant melanoma is a leading cause of skin cancer‐related death. In over 30% of cases, the melanoma is invasive and has a metastatic phenotype. KCNQ1 overlapping transcript 1 (KCNQ1OT1) was previously identified as an oncogenic… read more here.
Keywords: malignant melanoma; melanoma; kcnq1ot1 sponges; 34a promote ... See more keywords
Safety assessment of anticancer drugs in association with radiotherapy in metastatic malignant melanoma: a real-life report
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DOI: 10.1007/s00280-019-03806-5
Abstract: PurposeTo assess the safety of the association of radiotherapy (RT) and systemic treatments for patients with metastatic malignant melanoma (mMM).MethodsA retrospective analysis included consecutive patients treated with palliative RT, and at least one line of… read more here.
Keywords: metastatic malignant; safety; association; anticancer drugs ... See more keywords
Early primary anorectal malignant melanoma treated with endoscopic submucosal dissection: a case report
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DOI: 10.1007/s00384-020-03546-6
Abstract: Background Anorectal malignant melanoma (ARMM) is a rare disease accounting for less than 1% of primary anorectal malignancies. Here we first present a case of early primary anorectal malignant melanoma completely resected by endoscopic submucosal… read more here.
Keywords: melanoma; endoscopic submucosal; anorectal malignant; primary anorectal ... See more keywords
Allyl isothiocyanate regulates lysine acetylation and methylation marks in an experimental model of malignant melanoma
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DOI: 10.1007/s00394-019-01925-6
Abstract: Objective(s) Isothiocyanates (ITCs) are biologically active plant secondary metabolites capable of mediating various biological effects including modulation of the epigenome. Our aim was to characterize the effect of allyl isothiocyanate (AITC) on lysine acetylation and… read more here.
Keywords: melanoma; methylation marks; malignant melanoma; lysine acetylation ... See more keywords
Sulforaphane and iberin are potent epigenetic modulators of histone acetylation and methylation in malignant melanoma
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Nutrition"
DOI: 10.1007/s00394-020-02227-y
Abstract: Objective(s) Growing evidence supports that isothiocyanates exert a wide range of bioactivities amongst of which is their capacity to interact with the epigenetic machinery in various cancers including melanoma. Our aim was to characterise the… read more here.
Keywords: melanoma; sulforaphane iberin; acetylation methylation; malignant melanoma ... See more keywords