Suramin, screened from an approved drug library, inhibits HuR functions and attenuates malignant phenotype of oral cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1877
Abstract: AU‐rich elements (ARE) exist in the 3′‐untranslated regions of the mRNA transcribed from cell growth‐related genes such as proto‐oncogenes, cyclin‐related genes, and growth factors. HuR binds and stabilizes ARE‐mRNA. HuR is expressed abundantly in cancer… read more here.
Keywords: attenuates malignant; oral cancer; drug; cancer cells ... See more keywords
ANKHD1 contributes to the malignant phenotype of triple‐negative breast cancer cells
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DOI: 10.1002/cbin.11844
Abstract: Ankyrin repeat and KH domain‐containing protein 1, ANKHD1, has been identified as a regulator of signaling pathways and cellular processes of relevance in carcinogenesis. However, the role of ANKHD1 in breast cancer remains unclear. The… read more here.
Keywords: breast; triple negative; breast cancer; malignant phenotype ... See more keywords
ADP ribosylation factor guanylate kinase 1 promotes the malignant phenotype of gastric cancer by regulating focal adhesion kinase activation.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119264
Abstract: AIMS ADP ribosylation factor guanylate kinase 1 (ASAP1), a phospholipid-dependent guanosine triphosphate (GTP)ase activating protein, has been reported to be involved in the development of various malignant tumors. However, the biological function of ASAP1 in… read more here.
Keywords: fak; kinase; malignant biological; biological behavior ... See more keywords
The protein kinase CK2 contributes to the malignant phenotype of cholangiocarcinoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Oncogenesis"
DOI: 10.1038/s41389-019-0171-x
Abstract: Cholangiocarcinoma (CCA) is a particularly aggressive hepatobiliary malignancy, for which the molecular mechanisms underlying the malignant phenotype are still poorly understood, and novel and effective therapeutic strategies are limited. The pro-survival protein kinase CK2 is… read more here.
Keywords: cholangiocarcinoma; cca; kinase ck2; protein kinase ... See more keywords
The Role of POPDC1 in the Progression of the Malignant Phenotype.
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DOI: 10.1111/bph.15403
Abstract: The Popeye Domain Containing Protein 1 (POPDC1), a tight junction-associated transmembrane protein with a unique binding site for cAMP, has been shown to act as a tumour suppressor in cancer cells. Through interaction with many… read more here.
Keywords: popdc1 progression; progression malignant; role popdc1; popdc1 ... See more keywords
HOTAIRM1 Maintained the Malignant Phenotype of tMSCs Transformed by GSCs via E2F7 by Binding to FUS
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/7734413
Abstract: Objective Mesenchymal stromal/stem cells (MSCs) are an important part of the glioma microenvironment and are involved in the malignant progression of glioma. In our previous study, we showed that MSCs can be induced to a… read more here.
Keywords: phenotype tmscs; tmscs; e2f7; malignant phenotype ... See more keywords
CLDN2 inhibits the metastasis of osteosarcoma cells via down-regulating the afadin/ERK signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Cell International"
DOI: 10.1186/s12935-018-0662-4
Abstract: BackgroundIn an earlier study, we investigated the expression of tight junction protein claudins (CLDNs) in human osteosarcoma (OS) cells, and the CLDN2 was found to be down-regulated in primary tumor cells compared with normal osteoblast cells. Here,… read more here.
Keywords: western blotting; expression; osteosarcoma cells; cldn2 ... See more keywords
Kallikrein-related peptidase 7 overexpression in melanoma cells modulates cell adhesion leading to a malignant phenotype
Sign Up to like & getrecommendations! Published in 2018 at "Biological Chemistry"
DOI: 10.1515/hsz-2017-0339
Abstract: Abstract We recently reported that human melanoma cells, but not benign melanocytes, aberrantly express kallikrein-related peptidase 7 (KLK7). Here, we show a KLK7 overexpression-mediated decrease of cell adhesion to extracellular matrix binding proteins, associated with… read more here.
Keywords: melanoma; kallikrein related; cell adhesion; melanoma cells ... See more keywords
HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15152
Abstract: Human malignant mesothelioma (MM) is an aggressive cancer linked to asbestos and erionite exposure. We previously reported that High-Mobility Group Box-1 protein (HMGB1), a prototypic damage-associated molecular pattern, drives MM development and sustains MM progression.… read more here.
Keywords: hmgb1; mesothelioma; ethyl pyruvate; growth ... See more keywords
Promotion of malignant phenotype after disruption of the three-dimensional structure of cultured spheroids from colorectal cancer
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DOI: 10.18632/oncotarget.24641
Abstract: Individual and small clusters of cancer cells may detach from the edges of a main tumor and invade vessels, which can act as the origin of metastasis; however, the mechanism for this phenomenon is not… read more here.
Keywords: disruption; phenotype disruption; colorectal cancer; promotion malignant ... See more keywords
Overexpression of Multifunctional Protein p32 Promotes a Malignant Phenotype in Colorectal Cancer Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.642940
Abstract: p32 is a multifunctional and multicompartmental protein that has been found upregulated in numerous adenocarcinomas, including colorectal malignancy. High levels of p32 expression have been correlated with poor prognosis in colorectal cancer. However, the functions… read more here.
Keywords: colorectal cancer; p32; cancer cells; cancer ... See more keywords