Cytosolic TGM2 promotes malignant progression in gastric cancer by suppressing the TRIM21‐mediated ubiquitination/degradation of STAT1 in a GTP binding‐dependent modality
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DOI: 10.1002/cac2.12386
Abstract: Previous studies have revealed the critical role of transglutaminase 2 (TGM2) as a potential therapeutic target in cancers, but the oncogenic roles and underlying mechanisms of TGM2 in gastric cancer (GC) are not fully understood.… read more here.
Keywords: tgm2 promotes; malignant progression; cytosolic tgm2; promotes malignant ... See more keywords
Impact of human papillomaviruses (HPV) on recurrence rate and malignant progression of sinonasal papillomas
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DOI: 10.1002/cam4.3642
Abstract: Sinonasal papillomas are characterized by their potential for frequent recurrences and malignant progression. Currently, the role of human papillomavirus (HPV) infection in sinonasal papillomas is unclear. A study was conducted to elucidate the impact of… read more here.
Keywords: sinonasal; malignant progression; hpv infection; sinonasal papillomas ... See more keywords
HOXD13 promotes the malignant progression of colon cancer by upregulating PTPRN2
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.4078
Abstract: The homeobox (HOX) family plays an important role in multi‐biological processes, such as morphogenesis and tumors. However, the function of HOXD13 in colon cancer remains unclear. read more here.
Keywords: hoxd13 promotes; malignant progression; colon cancer; cancer ... See more keywords
Ulinastatin ameliorates the malignant progression of prostate cancer cells by blocking the RhoA/ROCK/NLRP3 pathway
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DOI: 10.1002/ddr.22010
Abstract: Prostate cancer is a male malignant tumor disease with high incidence and mortality. This study was designed to explore the effects of ulinastatin (UTI) on the malignant progression of prostate cancer and its relevant mechanism… read more here.
Keywords: cell; prostate cancer; prostate; malignant progression ... See more keywords
Ubiquitin ligase MARCH8 promotes the malignant progression of hepatocellular carcinoma through PTEN ubiquitination and degradation.
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DOI: 10.1002/mc.23546
Abstract: Membrane-associated ring-CH-type finger 8 (MARCH8) belongs to the MARCH family of membrane-bound E3 ubiquitin ligases. The N-terminus of MARCH family members contains the C4HC3 RING-finger domain, which can bind to E2 ubiquitin-conjugating enzymes, ubiquitinate substrate… read more here.
Keywords: hepatocellular carcinoma; hcc cells; malignant progression; hcc ... See more keywords
Smoking and IPMN malignant progression.
Sign Up to like & getrecommendations! Published in 2017 at "American journal of surgery"
DOI: 10.1016/j.amjsurg.2016.10.033
Abstract: BACKGROUND Patients with intraductal papillary mucinous neoplasm (IPMN) are at risk for invasive pancreatic cancer. We aim to characterize the impact of smoking on IPMN malignant progression. METHODS Patients undergoing pancreatic resection for IPMN (1991-2015)… read more here.
Keywords: non smokers; smoking ipmn; malignant progression; ipmn malignant ... See more keywords
Curbing tumorigenesis and malignant progression through the pharmacological control of the wound healing process.
Sign Up to like & getrecommendations! Published in 2017 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2017.01.003
Abstract: The prevention of cancer development and its progression is an urgent unmet medical need. Novel knowledge on the biology of cancer has evidenced that genetic changes occurring within cancer cells contribute, but are not sufficient,… read more here.
Keywords: curbing tumorigenesis; malignant progression; tumorigenesis malignant; cancer ... See more keywords
Impact of Resection on Survival of Isocitrate Dehydrogenase 1-Mutated World Health Organization Grade II Astrocytoma After Malignant Progression.
Sign Up to like & getrecommendations! Published in 2017 at "World neurosurgery"
DOI: 10.1016/j.wneu.2017.03.123
Abstract: OBJECTIVE To evaluate the impact of surgical resection and adjuvant treatment on the course of patients after malignant progression of previously treated isocitrate dehydrogenase 1 (IDH1)-mutated World Health Organization (WHO) grade II astrocytoma. METHODS This… read more here.
Keywords: world; malignant progression; resection; grade astrocytoma ... See more keywords
Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma
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DOI: 10.1038/srep44792
Abstract: Infiltrating low grade gliomas (LGGs) are heterogeneous in their behavior and the strategies used for clinical management are highly variable. A key factor in clinical decision-making is that patients with mutations in the isocitrate dehydrogenase… read more here.
Keywords: metabolic profiling; progression; mutation malignant; malignant progression ... See more keywords
CircRNA PRH1‐PRR4 stimulates RAB3D to regulate the malignant progression of NSCLC by sponging miR‐877‐5p
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DOI: 10.1111/1759-7714.14264
Abstract: Previous reports have confirmed the importance of circular RNA (circRNA) in the malignant progression of non‐small‐cell lung cancer (NSCLC). However, the role of circRNA PRH1‐PRR4 readthrough (circPRH1‐PRR4) in NSCLC progression was unclear. This study was… read more here.
Keywords: circrna; prh1 prr4; progression; malignant progression ... See more keywords
p53 protein accumulation predicts malignant progression in Barrett's metaplasia: a prospective study of 275 patients
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DOI: 10.1111/his.13193
Abstract: The purpose of this study was to determine prospectively whether p53 protein accumulation in biopsies of Barrett's metaplasia (BM) is a predictor of malignant progression, without relying on dysplasia grading. read more here.
Keywords: p53 protein; study; barrett metaplasia; malignant progression ... See more keywords