Cytosolic TGM2 promotes malignant progression in gastric cancer by suppressing the TRIM21‐mediated ubiquitination/degradation of STAT1 in a GTP binding‐dependent modality
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Communications"
DOI: 10.1002/cac2.12386
Abstract: Previous studies have revealed the critical role of transglutaminase 2 (TGM2) as a potential therapeutic target in cancers, but the oncogenic roles and underlying mechanisms of TGM2 in gastric cancer (GC) are not fully understood.… read more here.
Keywords: tgm2 promotes; malignant progression; cytosolic tgm2; promotes malignant ... See more keywords
Impact of human papillomaviruses (HPV) on recurrence rate and malignant progression of sinonasal papillomas
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DOI: 10.1002/cam4.3642
Abstract: Sinonasal papillomas are characterized by their potential for frequent recurrences and malignant progression. Currently, the role of human papillomavirus (HPV) infection in sinonasal papillomas is unclear. A study was conducted to elucidate the impact of… read more here.
Keywords: sinonasal; malignant progression; hpv infection; sinonasal papillomas ... See more keywords
HOXD13 promotes the malignant progression of colon cancer by upregulating PTPRN2
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.4078
Abstract: The homeobox (HOX) family plays an important role in multi‐biological processes, such as morphogenesis and tumors. However, the function of HOXD13 in colon cancer remains unclear. read more here.
Keywords: hoxd13 promotes; malignant progression; colon cancer; cancer ... See more keywords
KPNA5 Suppresses Malignant Progression of Ovarian Cancer Through Importing the PTPN4 Into the Nucleus
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DOI: 10.1002/cam4.70731
Abstract: Abnormal protein localization due to disrupted nucleoplasmic transport is common in tumor cells, but its mechanisms are not well understood. Nuclear pore complexes and nuclear transporter proteins are crucial for protein transport between the nucleus… read more here.
Keywords: cancer; kpna5 suppresses; progression ovarian; ovarian cancer ... See more keywords
Ulinastatin ameliorates the malignant progression of prostate cancer cells by blocking the RhoA/ROCK/NLRP3 pathway
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DOI: 10.1002/ddr.22010
Abstract: Prostate cancer is a male malignant tumor disease with high incidence and mortality. This study was designed to explore the effects of ulinastatin (UTI) on the malignant progression of prostate cancer and its relevant mechanism… read more here.
Keywords: cell; prostate cancer; prostate; malignant progression ... See more keywords
Ubiquitin ligase MARCH8 promotes the malignant progression of hepatocellular carcinoma through PTEN ubiquitination and degradation.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23546
Abstract: Membrane-associated ring-CH-type finger 8 (MARCH8) belongs to the MARCH family of membrane-bound E3 ubiquitin ligases. The N-terminus of MARCH family members contains the C4HC3 RING-finger domain, which can bind to E2 ubiquitin-conjugating enzymes, ubiquitinate substrate… read more here.
Keywords: hepatocellular carcinoma; hcc cells; malignant progression; hcc ... See more keywords
PKP2 induced by YAP/TEAD4 promotes malignant progression of gastric cancer
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DOI: 10.1002/mc.23751
Abstract: Gastric cancer (GC) exhibits significant heterogeneity and its prognosis remains dismal. Therefore, it is essential to investigate new approaches for diagnosing and treating GC. Desmosome proteins are crucial for the advancement and growth of cancer.… read more here.
Keywords: yap tead4; progression; gastric cancer; pkp2 ... See more keywords
IRTKS contributes to the malignant progression of cervical cancer cells
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DOI: 10.1007/s12032-024-02410-9
Abstract: Cervical cancer (CC), one of the most aggressive tumors in women, has high risk rates of recurrence and metastasis. It is essential to study the key genes and proteins involved in CC development. IRTKS, a… read more here.
Keywords: irtks contributes; cervical cancer; irtks; contributes malignant ... See more keywords
Smoking and IPMN malignant progression.
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DOI: 10.1016/j.amjsurg.2016.10.033
Abstract: BACKGROUND Patients with intraductal papillary mucinous neoplasm (IPMN) are at risk for invasive pancreatic cancer. We aim to characterize the impact of smoking on IPMN malignant progression. METHODS Patients undergoing pancreatic resection for IPMN (1991-2015)… read more here.
Keywords: non smokers; smoking ipmn; malignant progression; ipmn malignant ... See more keywords
Curbing tumorigenesis and malignant progression through the pharmacological control of the wound healing process.
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DOI: 10.1016/j.vph.2017.01.003
Abstract: The prevention of cancer development and its progression is an urgent unmet medical need. Novel knowledge on the biology of cancer has evidenced that genetic changes occurring within cancer cells contribute, but are not sufficient,… read more here.
Keywords: curbing tumorigenesis; malignant progression; tumorigenesis malignant; cancer ... See more keywords
Impact of Resection on Survival of Isocitrate Dehydrogenase 1-Mutated World Health Organization Grade II Astrocytoma After Malignant Progression.
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DOI: 10.1016/j.wneu.2017.03.123
Abstract: OBJECTIVE To evaluate the impact of surgical resection and adjuvant treatment on the course of patients after malignant progression of previously treated isocitrate dehydrogenase 1 (IDH1)-mutated World Health Organization (WHO) grade II astrocytoma. METHODS This… read more here.
Keywords: world; malignant progression; resection; grade astrocytoma ... See more keywords