Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109568
Abstract: Malignant rhabdoid tumors (MRTs) represent one of the most aggressive childhood malignancies. No effective treatment options are available, and prognosis is, therefore, dismal. Previous studies have demonstrated that tumor organoids capture the heterogeneity of patient… read more here.
Keywords: rhabdoid tumors; malignant rhabdoid; drug screening; organoid based ... See more keywords
Successful multimodality management of extrarenal extracranial malignant rhabdoid tumour of the left sciatic nerve mimicking a neurofibroma.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of neurosurgery"
DOI: 10.1080/02688697.2021.1981245
Abstract: Extrarenal extracranial malignant rhabdoid tumour (MRT) is a rare and highly aggressive tumour representing read more here.
Keywords: malignant rhabdoid; left sciatic; nerve; sciatic nerve ... See more keywords
Disseminated Congenital Malignant Rhabdoid Tumor Misdiagnosed as Multiple Congenital Hemangiomas.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000001587
Abstract: To the Editor: A congenital malignant rhabdoid tumor (MRT) is a rare and aggressive growth, which is fatal in almost all patients under the age of 1 year.1 A 1-day-old girl, born at term by… read more here.
Keywords: malignant rhabdoid; congenital hemangiomas; multiple congenital; congenital malignant ... See more keywords
FDG PET/CT Findings of Malignant Rhabdoid Tumor Arising From a Renal Allograft.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000004657
Abstract: ABSTRACT Malignant rhabdoid tumor of the kidney is a rare aggressive malignancy with poor prognosis. We describe FDG PET/CT findings in a case of malignant rhabdoid tumor of the renal allograft with regional lymph node… read more here.
Keywords: pet findings; malignant rhabdoid; rhabdoid tumor; fdg pet ... See more keywords
The Achilles Heel of Malignant Rhabdoid Tumors.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-19-0990
Abstract: Malignant rhabdoid tumors (MRT) are rare but deadly pediatric tumors characterized by mutations in the SMARCB1/SNF5/INI1/BAF47 gene. Currently, there are no targeted therapies for MRTs. In a previous issue of Cancer Research, Howard and colleagues… read more here.
Keywords: malignant rhabdoid; cancer; heel malignant; achilles heel ... See more keywords
Primary Adrenal Malignant Rhabdoid Tumor in a 14-Year-Old Female: A Case Report and Literature Review.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of surgical pathology"
DOI: 10.1177/10668969211024331
Abstract: Malignant rhabdoid tumor (MRT) is a rare, SWItch/sucrose nonfermentable-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1)-deficient, aggressive tumor, occurring predominantly in children below 3 years of age. Primary adrenal MRT is extremely… read more here.
Keywords: rhabdoid tumor; primary adrenal; old female; malignant rhabdoid ... See more keywords
RUNX1–Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Molecules and Cells"
DOI: 10.14348/molcells.2022.2031
Abstract: Malignant rhabdoid tumor (MRT) is a highly aggressive pediatric malignancy with no effective therapy. Therefore, it is necessary to identify a target for the development of novel molecule-targeting therapeutic agents. In this study, we report… read more here.
Keywords: runx1; malignant rhabdoid; mrt; survivin axis ... See more keywords
Current and Emerging Therapeutic Approaches for Extracranial Malignant Rhabdoid Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Management and Research"
DOI: 10.2147/cmar.s289544
Abstract: Abstract Extracranial malignant rhabdoid tumors (extracranial MRT) are rare, highly aggressive malignancies affecting mainly infants and children younger than 3 years. Common anatomic sites comprise the kidneys (RTK – rhabdoid tumor of kidney) and other… read more here.
Keywords: malignant rhabdoid; extracranial mrt; therapeutic approaches; extracranial malignant ... See more keywords
A Systematic Review and Meta-Analysis of Malignant Rhabdoid and Small Cell Undifferentiated Liver Tumors: A Rational for a Uniform Classification
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14020272
Abstract: Simple Summary Malignant rhabdoid tumors of the liver are very rare pediatric liver tumors with a devastating prognosis. It is currently unclear which histological subtypes of pediatric liver tumors belong to this entity and how… read more here.
Keywords: small cell; liver tumors; liver; malignant rhabdoid ... See more keywords
Human Malignant Rhabdoid Tumor Antigens as Biomarkers and Potential Therapeutic Targets
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14153685
Abstract: Simple Summary Atypical teratoid rhabdoid tumor (ATRT) is a deadly type of human pediatric brain cancer without effective treatments. ATRT is mainly linked to the inactivation of a tumor suppressor gene, SMARCB1; however, additional biomarkers… read more here.
Keywords: cell; malignant rhabdoid; rhabdoid tumor; cell lines ... See more keywords