Malononitrile dimer as a privileged reactant in design and skeletal diverse synthesis of heterocyclic motifs
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DOI: 10.1007/s11030-017-9807-y
Abstract: Malononitrile dimer as a precursor reactant has been extensively applied in the diversity-oriented synthesis of various heterocyclic motifs, bis-heterocyclic compounds, fused heterocycle derivatives, bicyclic bridged heterocyclic scaffolds, and highly substituted carbocyclic compounds. These remarkable products… read more here.
Keywords: dimer privileged; chemistry; malononitrile dimer; heterocyclic motifs ... See more keywords
Pot, atom and step economic (PASE) assembly of salicylaldehydes, malononitrile dimer and 4-hydroxypyridine-2(1H)-ones into medicinally relevant 5H-chromeno[2,3-b]pyridine scaffold
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DOI: 10.1007/s11030-019-09968-x
Abstract: The new multicomponent reaction (MCR) has been found: one-pot selective and efficient formation of the new 5-(4-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-substituted 5H-chromeno[2,3-b]pyridines in 61–97% yields directly from simple and easily available salicylaldehydes, malononitrile dimer and 4-hydroxypyridine-2(1H)-ones in small amount… read more here.
Keywords: hydroxypyridine ones; pyridine; dimer hydroxypyridine; chromeno pyridine ... See more keywords