Identification of histone malonylation in the human fetal brain and implications for diabetes‐induced neural tube defects
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1403
Abstract: Neural tube defects (NTDs) are severe congenital malformations. Diabetes during pregnancy is a risk factor for NTDs, but its mechanism remains elusive. Emerging evidence suggests that protein malonylation is involved in diabetes. Here, we report… read more here.
Keywords: malonylation; tube defects; neural tube; identification histone ... See more keywords
Global profiling of lysine-malonylated proteins in rice elucidates the immune-regulatory mechanisms of malonylation under herbivore or viral stresses.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.70050
Abstract: Lysine malonylation (Kmal), an evolutionarily conserved post-translational modification, serves as a critical regulator of cellular processes including transcriptional control, metabolic coordination, and enzyme activation. While Kmal sites have been mapped in rice (Oryza sativa L.)… read more here.
Keywords: rice; malonylated proteins; lysine malonylated; malonylation ... See more keywords
Systematic analysis of the lysine malonylome in Sanghuangporus sanghuang
Sign Up to like & getrecommendations! Published in 2021 at "BMC Genomics"
DOI: 10.1186/s12864-021-08120-0
Abstract: Background Sanghuangporus sanghuang is a well-known traditional medicinal mushroom associated with mulberry. Despite the properties of this mushroom being known for many years, the regulatory mechanisms of bioactive compound biosynthesis in this medicinal mushroom are… read more here.
Keywords: malonylation; sanghuang; lysine; analysis ... See more keywords
Global profiling of protein lysine malonylation in Toxoplasma gondii strains of different virulence and genetic backgrounds
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0010431
Abstract: Lysine malonylation is a post-translational modification (PTM), which regulates many cellular processes. Limited information is available about the level of lysine malonylation variations between Toxoplasma gondii strains of distinct genetic lineages. Yet, insights into such… read more here.
Keywords: strain; malonylation; virulence; lysine malonylation ... See more keywords
Lysine Malonylation and Its Links to Metabolism and Diseases
Sign Up to like & getrecommendations! Published in 2023 at "Aging and Disease"
DOI: 10.14336/ad.2022.0711
Abstract: Malonylation is a recently identified post-translational modification with malonyl-coenzyme A as the donor. It conserved both in prokaryotes and eukaryotes. Recent advances in the identification and quantification of lysine malonylation by bioinformatic analysis have improved… read more here.
Keywords: metabolism diseases; malonylation; lysine malonylation; links metabolism ... See more keywords
MSIT: Malonylation Sites Identification Tree
Sign Up to like & getrecommendations! Published in 2020 at "Current Bioinformatics"
DOI: 10.2174/1574893614666190730110747
Abstract: Post-Translational Modifications (PTMs), which include more than 450 types, can be regarded as the fundamental cellular regulation.Recently, experiments demonstrated that the lysine malonylation modification is a significant process in several organisms and cells. Meanwhile, malonylation… read more here.
Keywords: malonylation; msit; sites identification; malonylation sites ... See more keywords
SGLT2i alleviates epicardial adipose tissue inflammation by modulating ketone body–glyceraldehyde-3-phosphate dehydrogenase malonylation pathway
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cardiovascular Medicine"
DOI: 10.2459/jcm.0000000000001453
Abstract: Aims Inflammation in the epicardial adipose tissue (EAT) is a contributor to atrial fibrillation. Studies have reported that sodium glucose co-transporter 2 inhibitor (SGLT2i) can alleviate EAT inflammation. However, the mechanism remains elusive. This study… read more here.
Keywords: inflammation; ketone; sglt2i; malonyl coa ... See more keywords
Identification of the malonylation modification in Staphylococcus aureus and insight into the regulators in biofilm formation
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2025.1598098
Abstract: Background Post-translational modifications (PTMs) are critical regulators of bacterial biofilm formation, but the role of lysine malonylation (Kmal) in biofilm formation is still poorly understood. Methods In this study, we analyzed the dynamic changes of… read more here.
Keywords: malonylation; biofilm formation; formation; staphylococcus aureus ... See more keywords