Malt1 inactivation attenuates experimental colitis through the regulation of Th17 and Th1/17 cells
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DOI: 10.1007/s00011-018-1207-y
Abstract: Objective and designProtease activity of MALT lymphoma-translocation protein 1 (Malt1) plays an important role in the development of colitis, but the detailed mechanism has not been fully elucidated.MethodEffects of Malt1 protease on the activation of… read more here.
Keywords: th17 th1; th1 cells; malt1; colitis ... See more keywords
Long-Term MALT1 Inhibition in Adult Mice Without Severe Systemic Autoimmunity
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DOI: 10.1016/j.isci.2020.101557
Abstract: Summary The protease MALT1 is a key regulator of NF-κB signaling and a novel therapeutic target in autoimmunity and cancer. Initial enthusiasm supported by preclinical results with MALT1 inhibitors was tempered by studies showing that… read more here.
Keywords: term malt1; long term; malt1 inhibition; malt1 ... See more keywords
Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis
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DOI: 10.1038/s41598-017-12349-9
Abstract: Emerging evidence suggests that mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) is a key regulator of inflammatory diseases; however, the pathological role of MALT1 in rheumatoid arthritis (RA) is not well understood. Consequently, this protein… read more here.
Keywords: associated lymphoid; malt1; mucosa associated; rheumatoid arthritis ... See more keywords
In silico study on identification of novel MALT1 allosteric inhibitors
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DOI: 10.1039/c9ra07036b
Abstract: Paliperidone was screened as an effective and selective drug that can treat MALT1-driven cancer or autoimmune diseases. read more here.
Keywords: silico study; malt1; novel malt1; study identification ... See more keywords
A patent review of MALT1 inhibitors (2013-present).
Sign Up to like & getrecommendations! Published in 2021 at "Expert opinion on therapeutic patents"
DOI: 10.1080/13543776.2021.1951703
Abstract: INTRODUCTION MALT1 is the only human paracaspase, a protease with unique cleavage activity and substrate specificity. As a key regulator of immune responses, MALT1 has attracted attention as an immune modulatory target for the treatment… read more here.
Keywords: patent review; review malt1; malt1; inhibitors 2013 ... See more keywords
Porcine Reproductive and Respiratory Syndrome Virus Adapts Antiviral Innate Immunity via Manipulating MALT1
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DOI: 10.1128/mbio.00664-22
Abstract: PRRSV is a major swine pathogen, suppresses innate immunity, and causes persistent infection and coinfection with other pathogens. As a central immune mediator, MALT1 plays essential roles in regulating immunity and inflammation. ABSTRACT To fulfill… read more here.
Keywords: malt1; prrsv; infection; immunity ... See more keywords
AB0098 THE EFFECT OF MALT1-DEFICIENCY ON THE EFFECTOR PHASE OF EXPERIMENTAL AUTOIMMUNE ARTHRITIS
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.1439
Abstract: Background: The paracaspase Malt1 is a cysteine protease, which forms a complex leading to the activation of the in proinflammatory transcription factor NF-κB in lymphocytes with CARMA1 and Bcl10. Previously, we showed that the myeloid… read more here.
Keywords: autoantibody; deficiency; arthritis; effector phase ... See more keywords
Combining precision oncology and immunotherapy by targeting the MALT1 protease
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005442
Abstract: An innovative strategy for cancer therapy is to combine the inhibition of cancer cell-intrinsic oncogenic signaling with cancer cell-extrinsic immunological activation of the tumor microenvironment (TME). In general, such approaches will focus on two or… read more here.
Keywords: oncology; cell; malt1; immunotherapy ... See more keywords
Abstract 3914: BTK and MALT1 are critical for cell adhesion and dissemination in mantle cell lymphoma
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DOI: 10.1158/1538-7445.am2023-3914
Abstract: Bruton’s tyrosine kinase (BTK) is a great target in mantle cell lymphoma (MCL). This is evident by multiple FDA approvals of covalent BTK inhibitors (BTKi, e.g. ibrutinib, acalabrutinib and zanubrutinib) and recent exciting clinical data… read more here.
Keywords: cell; malt1; growth; btki ... See more keywords
Abstract 6156: MALT1 protease inhibition overcomes BTK inhibitor resistance and shows synergistic activity with venetoclax in models of B cell lymphoma and leukemia
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6156
Abstract: Introduction: Specific B cell malignancies, including CLL and the aggressive non-GCB subtype of DLBCL, are driven by constitutive activation of the B cell receptor (BCR) pathway and the transcription factor NF-κB. Pharmacological inhibition of MALT1… read more here.
Keywords: cell; malt1; inhibition; abbv malt1 ... See more keywords
Abstract PO-49: Discovery of JNJ-67856633: A novel, first-in-class MALT1 protease inhibitor for the treatment of B-cell lymphomas
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/2643-3249.lymphoma20-po-49
Abstract: Introduction: Constitutive activation of the classical nuclear factor kappa-light-chain-enhancer of activated B cells (NF κB) pathway is a clear driver of B-cell lymphomas, especially the aggressive activated B-cell (ABC) subtype of diffuse large B-cell lymphoma… read more here.
Keywords: dlbcl; malt1; cell; jnj 67856633 ... See more keywords