Malt1 inactivation attenuates experimental colitis through the regulation of Th17 and Th1/17 cells
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation Research"
DOI: 10.1007/s00011-018-1207-y
Abstract: Objective and designProtease activity of MALT lymphoma-translocation protein 1 (Malt1) plays an important role in the development of colitis, but the detailed mechanism has not been fully elucidated.MethodEffects of Malt1 protease on the activation of… read more here.
Keywords: th17 th1; th1 cells; malt1; colitis ... See more keywords
Long-Term MALT1 Inhibition in Adult Mice Without Severe Systemic Autoimmunity
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DOI: 10.1016/j.isci.2020.101557
Abstract: Summary The protease MALT1 is a key regulator of NF-κB signaling and a novel therapeutic target in autoimmunity and cancer. Initial enthusiasm supported by preclinical results with MALT1 inhibitors was tempered by studies showing that… read more here.
Keywords: term malt1; long term; malt1 inhibition; malt1 ... See more keywords
Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12349-9
Abstract: Emerging evidence suggests that mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) is a key regulator of inflammatory diseases; however, the pathological role of MALT1 in rheumatoid arthritis (RA) is not well understood. Consequently, this protein… read more here.
Keywords: associated lymphoid; malt1; mucosa associated; rheumatoid arthritis ... See more keywords
In silico study on identification of novel MALT1 allosteric inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra07036b
Abstract: Paliperidone was screened as an effective and selective drug that can treat MALT1-driven cancer or autoimmune diseases. read more here.
Keywords: silico study; malt1; novel malt1; study identification ... See more keywords
A patent review of MALT1 inhibitors (2013-present).
Sign Up to like & getrecommendations! Published in 2021 at "Expert opinion on therapeutic patents"
DOI: 10.1080/13543776.2021.1951703
Abstract: INTRODUCTION MALT1 is the only human paracaspase, a protease with unique cleavage activity and substrate specificity. As a key regulator of immune responses, MALT1 has attracted attention as an immune modulatory target for the treatment… read more here.
Keywords: patent review; review malt1; malt1; inhibitors 2013 ... See more keywords
An updated patent review of MALT1 inhibitors (2021–present)
Sign Up to like & getrecommendations! Published in 2025 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2025.2484371
Abstract: ABSTRACT Introduction MALT1 paracaspase acts as a molecular scaffold and a proteolytic enzyme in immune cells. MALT1 has emerged as a promising drug target for cancer therapy, and especially for targeting MALT1 in aggressive lymphomas.… read more here.
Keywords: potent selective; review; malt1 inhibitors; malt1 ... See more keywords
PRRSV utilizes MALT1-regulated autophagy flux to switch virus spread and reserve
Sign Up to like & getrecommendations! Published in 2024 at "Autophagy"
DOI: 10.1080/15548627.2024.2386195
Abstract: ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV) is a major swine pathogen, which can survive host antiviral immunity with various mechanisms. PRRSV infection induces macroautophagy/autophagy, facilitating virus replication. MALT1, a central immune regulator, was… read more here.
Keywords: autophagy flux; malt1; virus; infection ... See more keywords
Porcine Reproductive and Respiratory Syndrome Virus Adapts Antiviral Innate Immunity via Manipulating MALT1
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.00664-22
Abstract: PRRSV is a major swine pathogen, suppresses innate immunity, and causes persistent infection and coinfection with other pathogens. As a central immune mediator, MALT1 plays essential roles in regulating immunity and inflammation. ABSTRACT To fulfill… read more here.
Keywords: malt1; prrsv; infection; immunity ... See more keywords
AB0098 THE EFFECT OF MALT1-DEFICIENCY ON THE EFFECTOR PHASE OF EXPERIMENTAL AUTOIMMUNE ARTHRITIS
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.1439
Abstract: Background: The paracaspase Malt1 is a cysteine protease, which forms a complex leading to the activation of the in proinflammatory transcription factor NF-κB in lymphocytes with CARMA1 and Bcl10. Previously, we showed that the myeloid… read more here.
Keywords: autoantibody; deficiency; arthritis; effector phase ... See more keywords
Combining precision oncology and immunotherapy by targeting the MALT1 protease
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005442
Abstract: An innovative strategy for cancer therapy is to combine the inhibition of cancer cell-intrinsic oncogenic signaling with cancer cell-extrinsic immunological activation of the tumor microenvironment (TME). In general, such approaches will focus on two or… read more here.
Keywords: oncology; cell; malt1; immunotherapy ... See more keywords
Inhibition of MALT1 and BCL2 Induces Synergistic Antitumor Activity in Models of B-Cell Lymphoma
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-23-0518
Abstract: Abstract The activated B cell (ABC) subset of diffuse large B-cell lymphoma (DLBCL) is characterized by chronic B-cell receptor signaling and associated with poor outcomes when treated with standard therapy. In ABC-DLBCL, MALT1 is a… read more here.
Keywords: cell lymphoma; malt1; cell; malt1 bcl2 ... See more keywords