Long-Term MALT1 Inhibition in Adult Mice Without Severe Systemic Autoimmunity
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DOI: 10.1016/j.isci.2020.101557
Abstract: Summary The protease MALT1 is a key regulator of NF-κB signaling and a novel therapeutic target in autoimmunity and cancer. Initial enthusiasm supported by preclinical results with MALT1 inhibitors was tempered by studies showing that… read more here.
Keywords: term malt1; long term; malt1 inhibition; malt1 ... See more keywords
Pharmacological Inhibition of MALT1 Ameliorates Autoimmune Pathogenesis and Can Be Uncoupled From Effects on Regulatory T-Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.875320
Abstract: MALT1 forms part of a central signaling node downstream of immunoreceptor tyrosine-based activation motif (ITAM)-containing receptors, across a broad range of immune cell subsets, and regulates NF-κB driven transcriptional responses via dual scaffolding-protease activity. Allosteric… read more here.
Keywords: malt1; inhibition; regulatory cells; inhibition malt1 ... See more keywords