LAUSR

Characterization of maltose‐binding protein–fused heparinases with enhanced thermostability by application of rigid and flexible linkers

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0 Published in 2024 at "Biotechnology and Applied Biochemistry"

DOI: 10.1002/bab.2642

Abstract: Heparinases, including heparinases I–III (HepI, HepII, and HepIII, respectively), are important tools for producing low‐molecular‐weight heparin, an improved anticoagulant. The poor thermostability of heparinases significantly hinders their industrial and laboratory applications. To improve the thermostability… read more here.

Keywords: thermostability; linker; binding protein; mbp fused ... See more keywords

Argentinian small ruminant lentivirus (SRLV) p55gag antigen fused to maltose binding protein to use in SRLV serological confirmatory diagnosis.

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0 Published in 2021 at "Virus research"

DOI: 10.1016/j.virusres.2021.198332

Abstract: The complete gag gene from small ruminant lentiviruses (SRLV) encodes for a polyprotein of 55 kDa, known as p55gag. p55gag presents multiple antigenic epitopes, which can be recognized by antibodies, increasing the opportunity to detect SRLV-positive… read more here.

Keywords: srlv; small ruminant; p55gag; binding protein ... See more keywords

Open and Closed Form of Maltose Binding Protein in Its Native and Molten Globule State As Studied by Electron Paramagnetic Resonance Spectroscopy.

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1 Published in 2018 at "Biochemistry"

DOI: 10.1021/acs.biochem.8b00322

Abstract: An intensively investigated intermediate state of protein folding is the molten globule (MG) state, which contains secondary but hardly any tertiary structure. In previous work, we have determined the distances between interacting spins within maltose… read more here.

Keywords: state; open closed; mbp; closed form ... See more keywords

Programming xenon diffusion in maltose binding protein.

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1 Published in 2022 at "Biophysical journal"

DOI: 10.2139/ssrn.4145567

Abstract: Protein interiors contain void space that can bind small gas molecules. Determination of gas pathways and kinetics in proteins has been an intriguing and challenging task. Here, we combined computational methods and the hyper-CEST NMR… read more here.

Keywords: binding protein; diffusion; exchange; maltose binding ... See more keywords

CpG ODN1826 as a Promising Mucin1-Maltose-Binding Protein Vaccine Adjuvant Induced DC Maturation and Enhanced Antitumor Immunity

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0 Published in 2018 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms19030920

Abstract: Mucin 1 (MUC1), being an oncogene, is an attractive target in tumor immunotherapy. Maltose binding protein (MBP) is a potent built-in adjuvant to enhance protein immunogenicity. Thus, a recombinant MUC1 and MBP antitumor vaccine (M-M)… read more here.

Keywords: protein; maturation; binding protein; vaccine ... See more keywords