Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase &agr;2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo
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DOI: 10.1161/circulationaha.118.033552
Abstract: Background: Fundc1 (FUN14 domain containing 1), an outer mitochondrial membrane protein, is important for mitophagy and mitochondria-associated endoplasmic reticulum membranes (MAMs). The roles of Fundc1 and MAMs in diabetic hearts remain unknown. The aims of… read more here.
Keywords: formation; protein kinase; fundc1; amp activated ... See more keywords
PDK4 Augments ER–Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity
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DOI: 10.2337/db18-0363
Abstract: Mitochondria-associated endoplasmic reticulum membrane (MAM) is a structural link between mitochondria and endoplasmic reticulum (ER). MAM regulates Ca2+ transport from the ER to mitochondria via an IP3R1-GRP75-VDAC1 complex–dependent mechanism. Excessive MAM formation may cause mitochondrial… read more here.
Keywords: skeletal muscle; mam formation; insulin signaling; formation ... See more keywords
The Effects of PP2A Disruption on ER-Mitochondria Contact and Mitochondrial Functions in Neuronal-like Cells
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DOI: 10.3390/biomedicines11041011
Abstract: Mitochondria-associated membranes (MAMs) regulate several cellular processes, including calcium homeostasis and mitochondrial function, and dynamics. While MAMs are upregulated in Alzheimer’s disease (AD), the mechanisms underlying this increase remain unknown. A possible mechanism may include… read more here.
Keywords: mam formation; effects pp2a; pp2a; function dynamics ... See more keywords
GRP75-faciliated Mitochondria-associated ER Membrane (MAM) Integrity controls Cisplatin-resistance in Ovarian Cancer Patients
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DOI: 10.7150/ijbs.71571
Abstract: Background: Control of ER-mitochondrial Ca2+ fluxes is a critical checkpoint to determine cell fate under stress. The 75-kDa glucose-regulated protein (GRP75) is a key tether protein facilitating mitochondria-associated ER membrane (MAM) formation through the IP3R-GRP75-VDAC1… read more here.
Keywords: mam formation; mam; resistance; grp75 ... See more keywords