DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.04.044
Abstract: Background The mitochondrial associated endoplasmic reticulum (ER) membrane (MAM) provides a platform for communication between the mitochondria and ER, and it plays a vital role in many biological functions. Disulphide-bond A oxidoreductase-like protein (DsbA-L), expressed… read more here.
Keywords: dsba; maintaining mam; microscopy; high glucose ... See more keywords
DsbA-L alleviated tubular injury in diabetic nephropathy via activating mitophagy through maintain MAM integrity.
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DOI: 10.1042/cs20220787
Abstract: Mitochondria-associated endoplasmic reticulum membranes (MAMs) regulate ATG14- and Beclin1-mediated mitophagy and play key roles in the development of diabetic nephropathy (DN). DsbA-L is mainly located in MAMs and plays a role in renoprotection, but whether… read more here.
Keywords: dsba; mice; mam integrity; helz2 ... See more keywords
Glycine Supplementation in Obesity Worsens Glucose Intolerance through Enhanced Liver Gluconeogenesis
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DOI: 10.3390/nu15010096
Abstract: Interactions between mitochondria and the endoplasmic reticulum, known as MAMs, are altered in the liver in obesity, which contributes to disruption of the insulin signaling pathway. In addition, the plasma level of glycine is decreased… read more here.
Keywords: glycine supplementation; glycine; mam integrity; obesity ... See more keywords