N-Substituted 5-(1H-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs: Mechanism of Action.
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DOI: 10.1021/acs.jmedchem.1c01563
Abstract: Here, we describe the first systematic study on the mechanism of substrate-selective inhibition of mammalian ALOX15 orthologs. For this purpose, we prepared a series of N-substituted 5-(1H-indol-2-yl)anilines and found that (N-(5-(1H-indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamates and their monofluorinated analogues… read more here.
Keywords: inhibitors linoleate; mammalian alox15; mechanism; substituted indol ... See more keywords
The Reaction Specificity of Mammalian ALOX15 Orthologs is Changed During Late Primate Evolution and These Alterations Might Offer Evolutionary Advantages for Hominidae
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DOI: 10.3389/fcell.2022.871585
Abstract: Arachidonic acid lipoxygenases (ALOXs) have been implicated in the immune response of mammals. The reaction specificity of these enzymes is decisive for their biological functions and ALOX classification is based on this enzyme property. Comparing… read more here.
Keywords: mammalian alox15; acid; evolution; reaction specificity ... See more keywords
Conformational Heterogeneity and Cooperative Effects of Mammalian ALOX15
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DOI: 10.3390/ijms22063285
Abstract: Arachidonic acid lipoxygenases (ALOXs) have been suggested to function as monomeric enzymes, but more recent data on rabbit ALOX15 indicated that there is a dynamic monomer-dimer equilibrium in aqueous solution. In the presence of an… read more here.
Keywords: heterogeneity cooperative; mammalian alox15; rabbit alox15; cooperative effects ... See more keywords