Recurrent loss of HMGCS2 shows that ketogenesis is not essential for the evolution of large mammalian brains
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DOI: 10.7554/elife.38906
Abstract: Apart from glucose, fatty acid-derived ketone bodies provide metabolic energy for the brain during fasting and neonatal development. We investigated the evolution of HMGCS2, the key enzyme required for ketone body biosynthesis (ketogenesis). Unexpectedly, we… read more here.
Keywords: evolution; evolution large; large mammalian; ketogenesis ... See more keywords