Synthetic mRNA‐Based Systems in Mammalian Cells
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Biosystems"
DOI: 10.1002/adbi.201900247
Abstract: Living organisms are programmed to perform multiple functions by sensing intra‐ and extra‐cellular environments and by controlling gene expressions. Synthetic biologists aim to program cells by mimicking, designing, and constructing genetic circuits. Synthetic mRNA‐based genetic… read more here.
Keywords: based systems; synthetic mrna; mrna based; systems mammalian ... See more keywords
A Decade of Advances in Single-Cell Nanocoating for Mammalian Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100347
Abstract: Strategic advances in the single-cell nanocoating of mammalian cells have noticeably been made during the last decade, and many potential applications have been demonstrated. Various cell-coating strategies have been proposed via adaptation of reported methods… read more here.
Keywords: single cell; decade; nanocoating mammalian; mammalian cells ... See more keywords
Compressed Cells Facilitate Adhesion Through Glycocalyx
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202413586
Abstract: Exposed to mechanical confinement, mammalian cells can establish remarkable unspecific adhesion, which is independent of integrins. How cells facilitate such adhesion remains unclear. Here, it is investigated how mammalian cells exposed to compression initiate unspecific… read more here.
Keywords: unspecific adhesion; facilitate adhesion; adhesion; cells facilitate ... See more keywords
Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202502593
Abstract: Cas12j‐8 is a compact Cas nuclease discovered from the metagenome of giant bacteriophages, consisting of only 717 amino acids and recognizing the ‘5‐TTN‐3′ protospacer adjacent motif (PAM) sequence. However, its low gene editing efficiency in… read more here.
Keywords: genome modulation; cas12j versatile; engineered cas12j; versatile platform ... See more keywords
Prime editing in plants and mammalian cells: Mechanism, achievements, limitations, and future prospects
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200032
Abstract: Clustered, regularly interspaced, short palindromic repeat (CRISPR)/CRISPR‐associated protein (CRISPR/Cas) system has revolutionized genetic research in the life sciences. Four classes of CRISPR/Cas‐derived genome editing agents, such as nuclease, base editor, recombinase, and prime editor have… read more here.
Keywords: genome editing; crispr; prime editing; plants mammalian ... See more keywords
Esterified Trehalose Analogues Protect Mammalian Cells from Heat Shock
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700302
Abstract: Trehalose is a disaccharide produced by many organisms to better enable them to survive environmental stresses, including heat, cold, desiccation, and reactive oxygen species. Mammalian cells do not naturally biosynthesize trehalose; however, when introduced into… read more here.
Keywords: trehalose analogues; esterified trehalose; heat shock; mammalian cells ... See more keywords
Evaluation of the mutagenic effects of Molnupiravir and N4‐hydroxycytidine in bacterial and mammalian cells by HiFi sequencing
Sign Up to like & getrecommendations! Published in 2022 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22510
Abstract: Molnupiravir (MOV) is used to treat COVID‐19. In cells, MOV is converted to the ribonucleoside analog N4‐hydroxycytidine (NHC) and incorporated into the SARS‐CoV‐2 RNA genome during its replication, resulting in RNA mutations. The widespread accumulation… read more here.
Keywords: molnupiravir hydroxycytidine; mutagenic effects; effects molnupiravir; evaluation mutagenic ... See more keywords
Do Gadolinium‐Based Contrasts Represent a High Risk for Genotoxicity in Mammalian Cells? A Systematic Review
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4814
Abstract: The scientific rationale for this review stems from the increasing global use of gadolinium‐based contrast agents in medical imaging and the concerns over the long‐term environmental accumulation of gadolinium waste, which may pose biological risks.… read more here.
Keywords: based contrasts; review; gadolinium; mammalian cells ... See more keywords
Glyoxylate reductase/hydroxypyruvate reductase regulates the free d-aspartate level in mammalian cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30110
Abstract: Multiple d-amino acids are present in mammalian cells, and these compounds have distinctive physiological functions. Among the free d-amino acids identified in mammals, d-aspartate plays critical roles in the neuroendocrine and endocrine systems, as well… read more here.
Keywords: aspartate; reductase; reductase hydroxypyruvate; mammalian cells ... See more keywords
A new functional role of mitochondria-anchored protein ligase in peroxisome morphology in mammalian cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30114
Abstract: Mitochondria and peroxisomes are metabolically interconnected and functionally active subcellular organelles. These two dynamic organelles, share a number of common biochemical functions such as β-oxidation of fatty acids and detoxification of peroxides. The biogenesis and… read more here.
Keywords: mapl; fission; mitochondria anchored; morphology ... See more keywords
Surface-Initiated Synthesis of Cell-Specific Glycopolymers using Live Mammalian Cells as Templates.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202200881
Abstract: Molecular recognition is an important process in life activities where specificity is the key. However, the method to gain specificity are often complex and time-consuming. Here, we have developed a novel, versatile and effective way… read more here.
Keywords: cell; initiated synthesis; mammalian cells; specific glycosurfaces ... See more keywords