A Tale of Division and Polarization in the Mammalian Embryo.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.01.008
Abstract: The first cell fate choice in mouse development is the segregation of the embryonic inner cell mass and the extra-embryonic trophectoderm. In this issue of Developmental Cell, Korotkevic and colleagues (2017) show that the interplay… read more here.
Keywords: tale division; polarization; mammalian embryo; division polarization ... See more keywords
Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04155-2
Abstract: A fundamental question in developmental and stem cell biology concerns the origin and nature of signals that initiate asymmetry leading to pattern formation and self-organization. Instead of having prominent pre-patterning determinants as present in model… read more here.
Keywords: pattern formation; tracing origin; origin heterogeneity; mammalian embryo ... See more keywords
Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23653-4
Abstract: Generating properly differentiated embryonic structures in vitro from pluripotent stem cells remains a challenge. Here we show that instruction of aggregates of mouse embryonic stem cells with an experimentally engineered morphogen signalling centre, that functions… read more here.
Keywords: signalling centre; mammalian embryo; morphogen signalling; stem ... See more keywords
An Alternative Way to Improve Mammalian Embryo Development In Vitro: Culture of Zona Pellucida-Free Embryos.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular reprogramming"
DOI: 10.1089/cell.2022.0012
Abstract: An increasing number of data proves that the presence of the zona pellucida is not essential to mammalian embryo production, including maturation, fertilization, and embryo culture. In fact, the structure of the zona pellucida of… read more here.
Keywords: culture; zona pellucida; zona; free embryos ... See more keywords
Initial source of heterogeneity in a model for cell fate decision in the early mammalian embryo
Sign Up to like & getrecommendations! Published in 2022 at "Interface Focus"
DOI: 10.1098/rsfs.2022.0010
Abstract: During development, cells from a population of common progenitors evolve towards different fates characterized by distinct levels of specific transcription factors, a process known as cell differentiation. This evolution is governed by gene regulatory networks… read more here.
Keywords: cell fate; cell; heterogeneity; source ... See more keywords
Symmetry Breaking in the Mammalian Embryo.
Sign Up to like & getrecommendations! Published in 2018 at "Annual review of cell and developmental biology"
DOI: 10.1146/annurev-cellbio-100617-062616
Abstract: We present an overview of symmetry breaking in early mammalian development as a continuous process from compaction to specification of the body axes. While earlier studies have focused on individual symmetry-breaking events, recent advances enable… read more here.
Keywords: mammalian development; breaking mammalian; mammalian embryo; symmetry breaking ... See more keywords