The exploration of N6-deoxyadenosine methylation in mammalian genomes
Sign Up to like & getrecommendations! Published in 2021 at "Protein & Cell"
DOI: 10.1007/s13238-021-00866-3
Abstract: N6-methyladenine (N6-mA, m6dA, or 6mA), a prevalent DNA modification in prokaryotes, has recently been identified in higher eukaryotes, including mammals. Although 6mA has been well-studied in prokaryotes, the function and regulatory mechanism of 6mA in… read more here.
Keywords: mammalian genomes; exploration deoxyadenosine; methylation; methylation mammalian ... See more keywords
Genome-wide survey of tyrosine phosphatases in thirty mammalian genomes.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.110009
Abstract: The age of genomics has given us a wealth of information and the tools to study whole genomes. This, in turn, has facilitated genome-wide studies among organisms that were relatively less studied in the pre-genomic… read more here.
Keywords: mammalian genomes; genome wide; thirty mammalian; tyrosine phosphatases ... See more keywords
Whole genome comparative analysis of CpG islands in camelid and other mammalian genomes
Sign Up to like & getrecommendations! Published in 2019 at "Mammalian Biology"
DOI: 10.1016/j.mambio.2019.07.007
Abstract: Camels bear unique genotypes and phenotypes for adaptation in their environment, and as such could be very useful in the weather extremes accelerated by global climate change. Published sequences of Camelidae genomes provide an opportunity… read more here.
Keywords: whole genome; mammalian genomes; cgi; cgis ... See more keywords
Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl.
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature22063
Abstract: Mammalian genomes are spatially organized by CCCTC-binding factor (CTCF) and cohesin into chromatin loops and topologically associated domains, which have important roles in gene regulation and recombination. By binding to specific sequences, CTCF defines contact… read more here.
Keywords: mammalian genomes; cohesin; transcription ctcf; ctcf ... See more keywords
Direct decarboxylation of ten-eleven translocation-produced 5-carboxylcytosine in mammalian genomes forms a new mechanism for active DNA demethylation
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Science"
DOI: 10.1039/d1sc02161c
Abstract: DNA cytosine methylation (5-methylcytosine, 5mC) is the most important epigenetic mark in higher eukaryotes. 5mC in genomes is dynamically controlled by writers and erasers. DNA (cytosine-5)-methyltransferases (DNMTs) are responsible for the generation and maintenance of… read more here.
Keywords: mammalian genomes; dna; demethylation; ten eleven ... See more keywords
High-complexity regions in mammalian genomes are enriched for developmental genes
Sign Up to like & getrecommendations! Published in 2019 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty922
Abstract: Abstract Motivation Unique sequence regions are associated with genetic function in vertebrate genomes. However, measuring uniqueness, or absence of long repeats, along a genome is conceptually and computationally difficult. Here we use a variant of… read more here.
Keywords: mammalian genomes; high complexity; complexity; complexity regions ... See more keywords
The Three-Dimensional Organization of Mammalian Genomes.
Sign Up to like & getrecommendations! Published in 2017 at "Annual review of cell and developmental biology"
DOI: 10.1146/annurev-cellbio-100616-060531
Abstract: Animal development depends on not only the linear genome sequence that embeds millions of cis-regulatory elements, but also the three-dimensional (3D) chromatin architecture that orchestrates the interplay between cis-regulatory elements and their target genes. Compared… read more here.
Keywords: three dimensional; mammalian genomes; organization mammalian; dimensional organization ... See more keywords