Mammalian life depends on two distinct pathways of DNA damage tolerance
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2216055120
Abstract: Significance This report documents for the first time the essential and selective relevance of DNA damage tolerance (DDT) in warranting the survival of HSPCs and mammalian life. DDT prevents the accumulation of DNA damage in… read more here.
Keywords: dna damage; damage tolerance; mammalian life; damage ... See more keywords
Ketone bodies: A double-edged sword for mammalian life span.
Sign Up to like & getrecommendations! Published in 2023 at "Aging cell"
DOI: 10.1111/acel.13833
Abstract: Accumulating evidence suggests health benefits of ketone bodies, and especially for longevity. However, the precise role of endogenous ketogenesis in mammalian life span, and the safety and efficacy of the long-term exogenous supplementation of ketone… read more here.
Keywords: life span; edged sword; ketone bodies; mammalian life ... See more keywords