Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx1231
Abstract: Abstract Accuracy of protein synthesis is enabled by the selection of amino acids for tRNA charging by aminoacyl-tRNA synthetases (ARSs), and further enhanced by the proofreading functions of some of these enzymes for eliminating tRNAs… read more here.
Keywords: mammalian mitochondria; mischarged trnas; editing activity; essential mammalian ... See more keywords
Rescuing stalled mammalian mitoribosomes – what can we learn from bacteria?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.231811
Abstract: ABSTRACT In the canonical process of translation, newly completed proteins escape from the ribosome following cleavage of the ester bond that anchors the polypeptide to the P-site tRNA, after which the ribosome can be recycled… read more here.
Keywords: mammalian mitochondria; rescue; rescuing stalled; translation ... See more keywords
Nicotinamide adenine dinucleotide is transported into mammalian mitochondria
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.33246
Abstract: Mitochondrial NAD levels influence fuel selection, circadian rhythms, and cell survival under stress. It has alternately been argued that NAD in mammalian mitochondria arises from import of cytosolic nicotinamide (NAM), nicotinamide mononucleotide (NMN), or NAD… read more here.
Keywords: mammalian mitochondria; adenine dinucleotide; nicotinamide adenine; dinucleotide transported ... See more keywords