Isolation and characterization of mammalian orthoreovirus from bats in the United States
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28492
Abstract: Mammalian orthoreovirus (MRV) infects many mammalian species including humans, bats, and domestic animals. To determine the prevalence of MRV in bats in the United States, we screened more than 900 bats of different species collected… read more here.
Keywords: bats united; isolation characterization; mammalian orthoreovirus; united states ... See more keywords
Molecular characterization of an emerging reassortant mammalian orthoreovirus in China
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Virology"
DOI: 10.1007/s00705-020-04712-5
Abstract: Mammalian orthoreoviruses (MRVs) infect almost all mammals, and there are some reports on MRVs in China. In this study, a novel strain was identified, which was designated as HLJYC2017. The results of genetic analysis showed… read more here.
Keywords: characterization emerging; molecular characterization; reassortant mammalian; orthoreovirus china ... See more keywords
Inhibition of HIF-1α accumulation in prostate cancer cells is initiated during early stages of mammalian orthoreovirus infection.
Sign Up to like & getrecommendations! Published in 2021 at "Virology"
DOI: 10.1016/j.virol.2021.02.014
Abstract: Mammalian orthoreovirus (MRV) is a safe and effective cancer killing virus that has completed Phase I-III clinical trials against numerous cancer types. While many patients experience benefit from MRV therapy, pre-defined set points necessary for… read more here.
Keywords: mammalian orthoreovirus; inhibition hif; infection; inhibition ... See more keywords
Dissection of mammalian orthoreovirus µ2 reveals a self-associative domain required for binding to microtubules but not to factory matrix protein µNS
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DOI: 10.1371/journal.pone.0184356
Abstract: Mammalian orthoreovirus protein μ2 is a component of the viral core particle. Its activities include RNA binding and hydrolysis of the γ-phosphate from NTPs and RNA 5´-termini, suggesting roles as a cofactor for the viral… read more here.
Keywords: protein; matrix protein; association; factory matrix ... See more keywords