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   Articles with "mammalian target" as a keyword



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Probing the phosphatidylinositol 3‐kinase/mammalian target of rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low‐grade gliomas

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recommendations! Published in 2017 at "Cancer"

DOI: 10.1002/cncr.30909

Abstract: Activation of the phosphatidylinositol 3‐kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway is common in patients with low‐grade gliomas (LGGs), but agents that inhibit this pathway, including mTOR inhibitors, have not been studied in this population. read more here.

Keywords: gliomas; mammalian target; phosphatidylinositol kinase; target rapamycin ... See more keywords
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Angiotensin-Converting Enzyme Inhibitor Rapidly Ameliorates Depressive-Type Behaviors via Bradykinin-Dependent Activation of Mammalian Target of Rapamycin Complex 1

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recommendations! Published in 2020 at "Biological Psychiatry"

DOI: 10.1016/j.biopsych.2020.02.005

Abstract: BACKGROUND Angiotensin-converting enzyme inhibitors (ACEIs) are widely prescribed antihypertensive agents. Intriguingly, case reports and clinical trials have indicated that ACEIs, including captopril and lisinopril, may have a rapid mood-elevating effect in certain patients, but few… read more here.

Keywords: mammalian target; converting enzyme; angiotensin converting; stress model ... See more keywords
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Effects of the Mammalian Target of Rapamycin Inhibitor Everolimus on Hepatitis C Virus Replication In Vitro and In Vivo.

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recommendations! Published in 2017 at "Transplantation proceedings"

DOI: 10.1016/j.transproceed.2017.04.012

Abstract: BACKGROUND The influence of immunosuppressants on hepatitis C virus (HCV) re-infection after liver transplantation, particularly mammalian target of rapamycin inhibitors, remains unclear. The aim of our study was to analyze the influence of everolimus (EVR)… read more here.

Keywords: replication activity; mammalian target; hcv replication; target rapamycin ... See more keywords
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Prevalence of Cervical Infection With Human Papillomavirus of High Oncogenic Potential in Immunosuppressed Women on Renal Replacement Therapy With and Without Mammalian Target of Rapamycin Inhibitors.

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recommendations! Published in 2018 at "Transplantation proceedings"

DOI: 10.1016/j.transproceed.2018.02.124

Abstract: BACKGROUND Chronic immunosuppression constitutes a risk factor of human papillomavirus (HPV) related cervical cancer development. Maintenance immunosuppression with mammalian target of rapamycin (mTOR) inhibitors is associated with decreased incidence of de novo malignancies in kidney… read more here.

Keywords: cervical infection; mtor inhibitors; mammalian target; mtor ... See more keywords
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Early Switch to Mammalian Target of Rapamycin Inhibitors Is a Sustainable Treatment Approach in Renal Transplant Recipients: 7-Year Results.

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recommendations! Published in 2019 at "Transplantation proceedings"

DOI: 10.1016/j.transproceed.2019.01.098

Abstract: OBJECTIVE The aim of this study was to investigate the safety and sustainability of mammalian target of rapamycin inhibitor (m-TORi)-based treatment protocols in renal transplant patients. METHODS We retrospectively evaluated a total of 206 patients… read more here.

Keywords: sustainable treatment; mammalian target; treatment; target rapamycin ... See more keywords
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The mammalian target of rapamycin (mTOR) kinase mediates haloperidol-induced cataleptic behavior

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recommendations! Published in 2020 at "Translational Psychiatry"

DOI: 10.1038/s41398-020-01014-x

Abstract: The mammalian target of rapamycin (mTOR) is a ubiquitously expressed serine/threonine kinase protein complex (mTORC1 or mTORC2) that orchestrates diverse functions ranging from embryonic development to aging. However, its brain tissue-specific roles remain less explored.… read more here.

Keywords: haloperidol induced; rapamycin mtor; mammalian target; mtor ... See more keywords
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Anti-inflammatory Effects of Cardamonin in Ovarian Cancer Cells Are Mediated via mTOR Suppression.

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recommendations! Published in 2018 at "Planta medica"

DOI: 10.1055/a-0626-7426

Abstract: Cardamonin exhibits a variety of pharmacological activities including anti-inflammatory and antitumor, which are correlated with the inhibition of nuclear factor-kappaB and the mammalian target of rapamycin, respectively. However, whether the anti-inflammatory effects of cardamonin are… read more here.

Keywords: anti inflammatory; mammalian target; target; target rapamycin ... See more keywords
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Expression and significance of mammalian target of rapamycin in cutaneous squamous cell carcinoma and precancerous lesions

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recommendations! Published in 2021 at "Bioengineered"

DOI: 10.1080/21655979.2021.1984719

Abstract: ABSTRACT The aim of this study is to explore the role of mammalian target of rapamycin (mTOR) in cutaneous squamous cell carcinoma (CSCC), Bowen’s disease (BD), and actinic keratosis (AK) with squamous cell differentiation abnormality… read more here.

Keywords: mammalian target; expression; group; cscc ... See more keywords
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Characteristics of Lymphedema in Patients Treated with Mammalian Target of Rapamycin Inhibitors.

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recommendations! Published in 2021 at "Lymphatic research and biology"

DOI: 10.1089/lrb.2020.0069

Abstract: Purpose: To investigate the characteristics of lymphedema in patients treated with mammalian target of rapamycin (mTOR) inhibitors and delineate complex decongestive therapy (CDT) outcomes. Methods and Results: We retrospectively analyzed 24 patients with mTOR inhibitor-induced… read more here.

Keywords: treated mammalian; patients treated; mammalian target; mtor ... See more keywords
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Regulation of mammalian target of rapamycin on ferroptosis: from mechanism to therapeutics in septic cardiomyopathy

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recommendations! Published in 2022 at "Chinese Medical Journal"

DOI: 10.1097/cm9.0000000000002301

Abstract: Sepsis refers to multiple organ dysfunction caused by the host ’ s dysfunctional response to infection. Most importantly, myocardial injury in septic patients, that is, septic cardiomyopathy (SIC), accounts for 1/3 to 1/2 of the… read more here.

Keywords: target rapamycin; septic cardiomyopathy; regulation mammalian; mammalian target ... See more keywords
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Molecular interplay between hyperactive mammalian target of rapamycin signaling and Alzheimer’s disease neuropathology in the NS-Pten knockout mouse model

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recommendations! Published in 2018 at "NeuroReport"

DOI: 10.1097/wnr.0000000000001081

Abstract: Dysregulation of the PI3K/Akt/mTOR signaling cascade has been associated with the pathology of neurodegenerative disorders, specifically Alzheimer’s disease (AD). Both in-vivo models and post-mortem brain samples of individuals with AD have commonly shown hyperactivation of… read more here.

Keywords: alzheimer disease; mammalian target; hyperactive mammalian; pathology ... See more keywords