Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: An update
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Research Reviews"
DOI: 10.1002/med.21507
Abstract: Mammalian thioredoxin reductase (TrxR) enzymes are homodimeric flavin proteins sharing a unique yet essential selenocysteine residue at their C‐terminus. TrxRs, together with their endogenous substrate thioredoxins, play a crucial role in regulating diverse cellular redox… read more here.
Keywords: thioredoxin reductase; molecule; inhibitors mammalian; small molecule ... See more keywords
Oxidized Forms of Ergothioneine Are Substrates for Mammalian Thioredoxin Reductase
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11020185
Abstract: Ergothioneine (EGT) is a sulfur-containing amino acid analog that is biosynthesized in fungi and bacteria, accumulated in plants, and ingested by humans where it is concentrated in tissues under oxidative stress. While the physiological function… read more here.
Keywords: thioredoxin reductase; mammalian thioredoxin; egt; oxidized forms ... See more keywords