Conditional expression of Ki-RasG12V in the mammary epithelium of transgenic mice induces estrogen receptor alpha (ERα)-positive adenocarcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.252
Abstract: Appropriate ‘in vivo’ models are crucial for studying breast cancer biology and evaluating the efficacy of therapeutic agents. Thus we engineered a novel transgenic mouse line expressing the human Ki-Ras bearing an activating mutation (Ki-Ras(G12V))… read more here.
Keywords: mammary epithelium; conditional expression; transgenic mice; breast cancer ... See more keywords
Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling
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DOI: 10.1038/s41556-020-0505-0
Abstract: Macrophages are diverse immune cells that reside in all tissues. Although macrophages have been implicated in mammary-gland function, their diversity has not been fully addressed. By exploiting high-resolution three-dimensional imaging and flow cytometry, we identified… read more here.
Keywords: resident ductal; tissue resident; tissue; mammary epithelium ... See more keywords
The AKT1E17K Allele Promotes Breast Cancer in Mice
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DOI: 10.3390/cancers14112645
Abstract: Simple Summary The main finding reported in this manuscript is that the gain-of-function mutation AKT1E17K is a bona fide oncogene for mammary epithelium, being able to efficiently initiate breast cancer in mice. On the basis… read more here.
Keywords: mammary epithelium; cancer mice; breast cancer; akt1e17k ... See more keywords
Ochratoxin A and Citrinin Differentially Modulate Bovine Mammary Epithelial Cell Permeability and Innate Immune Function
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DOI: 10.3390/toxins14090640
Abstract: Frequent detection of mycotoxins ochratoxin A (OTA) and citrinin (CIT) in ruminant feed and feedstuff can be a potential threat to feed safety, animal performance and health. Ineffective biodegradation of these mycotoxins by rumen microflora… read more here.
Keywords: mammary epithelium; cell; expression; innate immune ... See more keywords