3D bioprinted mammary organoids and tumoroids in human mammary derived ECM hydrogels.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.06.017
Abstract: The extracellular matrix (ECM) of tissues is an important mediator of cell function. Moreover, understanding cellular dynamics within their specific tissue context is also important for developmental biology, cancer research, and regenerative medicine. However, robust… read more here.
Keywords: bioprinted mammary; mammary organoids; organoids tumoroids; tissue ... See more keywords
Establishing estrogen-responsive mouse mammary organoids from single Lgr5+ cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2016.08.001
Abstract: Recent evidence suggests that mammary cells expressing R-spondin receptor and Wnt pathway regulator Lgr5, regarded as a stem cell marker in multiple tissues, might represent mammary stem cells (MaSCs). Whether L gr5 marks a multipotent… read more here.
Keywords: lgr5 cells; mammary organoids; single lgr5; estrogen responsive ... See more keywords
Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Biology"
DOI: 10.1371/journal.pbio.2004986
Abstract: Distinct transcriptional states are maintained through organization of chromatin, resulting from the sum of numerous repressive and active histone modifications, into tightly packaged heterochromatin versus more accessible euchromatin. Polycomb repressive complex 2 (PRC2) is the… read more here.
Keywords: gland development; mammary gland; prc2; mammary organoids ... See more keywords