The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels
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DOI: 10.1002/advs.202405812
Abstract: NUMB is a tumor suppressor gene that functions by inhibiting the action of the NOTCH proto-oncogene and enhancing the levels and activity of the tumor suppressor protein p53. In breast cancer (BC), NUMB loss-of-function (LOF),… read more here.
Keywords: complex controls; mammary stem; crl7fbxw8 complex; tumor suppressor ... See more keywords
AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells
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DOI: 10.1016/j.stemcr.2020.12.002
Abstract: Summary Mammary gland ductal morphogenesis depends on the differentiation of mammary stem cells (MaSCs) into basal and luminal lineages. The AP-2γ transcription factor, encoded by Tfap2c, has a central role in mammary gland development but… read more here.
Keywords: mammary stem; maintenance; mammary gland; stem ... See more keywords
MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01059-5
Abstract: MicroRNA-mediated post-transcriptional regulation plays key roles in stem cell self-renewal and tumorigenesis. However, the in vivo functions of specific microRNAs in controlling mammary stem cell (MaSC) activity and breast cancer formation remain poorly understood. Here… read more here.
Keywords: tumorigenesis; breast; mammary stem; stem cell ... See more keywords
Mammary stem cells: angels or demons in mammary gland?
Sign Up to like & getrecommendations! Published in 2017 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/sigtrans.2016.38
Abstract: A highly dynamic development process exits within the epithelia of mammary gland, featuring morphogenetic variation during puberty, pregnancy, lactation, and regression. The identification of mammary stem cells (MaSCs) via lineage-tracing studies has substantiated a hierarchical… read more here.
Keywords: angels demons; mammary stem; mammary gland; stem ... See more keywords
Mammary Stem Cells and Breast Cancer Stem Cells: Molecular Connections and Clinical Implications
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DOI: 10.3390/biomedicines6020050
Abstract: Cancer arises from subpopulations of transformed cells with high tumor initiation and repopulation ability, known as cancer stem cells (CSCs), which share many similarities with their normal counterparts. In the mammary gland, several studies have… read more here.
Keywords: cancer stem; mammary stem; breast cancer; stem ... See more keywords
Plasticity and Potency of Mammary Stem Cell Subsets During Mammary Gland Development
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20092357
Abstract: It is now widely believed that mammary epithelial cell plasticity, an important physiological process during the stages of mammary gland development, is exploited by the malignant cells for their successful disease progression. Normal mammary epithelial… read more here.
Keywords: mammary stem; stem cell; mammary gland; gland development ... See more keywords