BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020)
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DOI: 10.1002/advs.202070033
Abstract: Mitophagy is a selective autophagic process for clearing damaged mitochondria and maintaining a healthy mitochondrial network. In article number https://doi.org/10.1002/advs.201903616, Qiang Chen, Chu‐Xia Deng, and co‐workers demonstrate breast cancer susceptibility gene 1 (BRCA1) facilitates mitophagy… read more here.
Keywords: inflammasome activation; brca1; mammary tumor; tumor metastasis ... See more keywords
Citronellol, an Acyclic Monoterpene Induces Mitochondrial-Mediated Apoptosis through Activation of Proapoptotic Factors in MCF-7 and MDA-MB-231 Human Mammary Tumor Cells
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DOI: 10.1080/01635581.2020.1800766
Abstract: Abstract The present study investigated the anticancer activity of citronellol (CT) by analyzing the mitochondrial-mediated activation of apoptosis in MCF-7 and MDA-MB-231 human mammary tumor cell lines. Cytotoxicity, cell growth, and apoptosis were determined by… read more here.
Keywords: mda 231; apoptosis; mcf mda; human mammary ... See more keywords
The role of microglia in 67NR mammary tumor-induced suppression of brain responses to immune challenges in female mice.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15830
Abstract: It is poorly understood how solid peripheral tumors affect brain neuroimmune responses despite the various brain-mediated side effects and higher rates of infection reported in cancer patients. We hypothesized that chronic low-grade peripheral tumor-induced inflammation… read more here.
Keywords: responses immune; mammary tumor; tumor induced; brain ... See more keywords
Abstract 1993: Gluthathione peroxidase 2 downregulation in the PyMT mammary tumor model leads to an aggressive phenotype due to stimulation of angiogenesis and tumor stemness via HIF1 alpha signaling
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-1993
Abstract: Breast tumors are known to undergo high levels of mitochondrial oxidative phosphorylation leading to accumulation of reactive oxygen species (ROS), which in turn potentiate cancer stem cells and chemoresistance. This was shown to be due… read more here.
Keywords: hif1; cancer; via hif1; tumor ... See more keywords
Abstract LB-036: Tetraspanin 5 expressing macrophages promote mammary tumor growth
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DOI: 10.1158/1538-7445.am2019-lb-036
Abstract: Rationale: Tetraspanins (TSPANs) have emerged as key players in regulating tumor cell migration, invasion, and metastasis. Whilst we know TSPANs are expressed by macrophages very little is known regarding their role in Tumor Associated Macrophages… read more here.
Keywords: cancer; tumor growth; tumor; tspan5 ... See more keywords
Identification of novel amyloidosis in dogs: α-S1-casein acquires amyloidogenicity in mammary tumor by overexpression and N-terminal truncation
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DOI: 10.1177/03009858221148511
Abstract: Mammary tumor–associated amyloidosis (MTAA) in dogs is characterized by amyloid deposition in the stroma of mammary adenoma or carcinoma; however, the amyloid precursor protein remains unknown. We attempted to identify an amyloid precursor protein and… read more here.
Keywords: acquires amyloidogenicity; casa1; mammary tumor; terminal truncation ... See more keywords
Ivermectin inhibits canine mammary tumor growth by regulating cell cycle progression and WNT signaling
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DOI: 10.1186/s12917-019-2026-2
Abstract: BackgroundMammary gland tumor is the most common spontaneous tumor in intact female dogs, and its poor prognosis remains a clinical challenge. Ivermectin, a well-known anti-parasitic agent, has been implicated as a potential anticancer agent in… read more here.
Keywords: canine mammary; cell cycle; mammary tumor; growth ... See more keywords
Re-expression of miR-200s in claudin‐low mammary tumor cells alters cell shape and reduces proliferation and invasion potentially through modulating other miRNAs and SUZ12 regulated genes
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DOI: 10.1186/s12935-021-01784-4
Abstract: Background MicroRNAs are a class of non-coding RNAs that regulate gene expression through binding to mRNAs and preventing their translation. One family of microRNAs known as the miR-200 family is an important regulator of epithelial… read more here.
Keywords: mir 200s; tumor cells; expression; mammary tumor ... See more keywords
Mammary tumor growth and proliferation are dependent on growth hormone in female SV40 C3(1) T-antigen mice.
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DOI: 10.1210/endocr/bqac174
Abstract: Female SV40 C3(1) T-antigen (C3(1)/TAg) transgenic mice develop mammary tumors that are molecularly similar to human basal-like breast cancers with 100% incidence at 16 weeks of age. To determine the requirement for growth hormone (GH)… read more here.
Keywords: growth; mammary tumor; growth hormone; mice ... See more keywords
Chronic exposure to low levels of parabens increases mammary cancer growth and metastasis in mice.
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DOI: 10.1210/endocr/bqad007
Abstract: Methylparaben (MP) and propylparaben (PP) are commonly used as food, cosmetic, and drug preservatives. These parabens are detected in the majority of US women and children, bind and activate estrogen receptors (ER), and stimulate mammary… read more here.
Keywords: metastasis; mammary cancer; mammary tumor; mice ... See more keywords
P-cadherin mutations are associated with high basal Wnt activity and stemness in canine mammary tumor cell lines
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DOI: 10.18632/oncotarget.26873
Abstract: ABSTRACT Purpose: To find underlying mutations causing highly-activated Wnt activity in mammary tumor cell lines associated with rounded morphology indicative of stemness/EMT. Methods: Stemness of high Wnt cell lines was confirmed using qPCR on selected… read more here.
Keywords: wnt; cell lines; wnt activity; mammary tumor ... See more keywords