Capturing the free energy of transition state stabilization: insights from the inhibition of mandelate racemase
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DOI: 10.1098/rstb.2022.0041
Abstract: Mandelate racemase (MR) catalyses the Mg2+-dependent interconversion of (R)- and (S)-mandelate. To effect catalysis, MR stabilizes the altered substrate in the transition state (TS) by approximately 26 kcal mol–1 (–ΔGtx), such that the upper limit… read more here.
Keywords: transition state; binding determinants; mandelate; mandelate racemase ... See more keywords