Diagnostic evaluation of fatal Balamuthia mandrillaris meningoencephalitis in a captive Bornean orangutan (Pongo pygmaeus) with identification of potential environmental source and evidence of chronic exposure
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DOI: 10.1007/s10329-020-00860-z
Abstract: A female Bornean orangutan ( Pongo pygmaeus ) aged 11 years and 6 months was examined by veterinarians after caretakers observed lethargy and facial grimacing. Within 72Â h the primate had left-sided hemiparesis that worsened over… read more here.
Keywords: bornean orangutan; balamuthia mandrillaris; pongo pygmaeus; orangutan pongo ... See more keywords
Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen Balamuthia mandrillaris
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DOI: 10.1128/mbio.02051-18
Abstract: Balamuthia mandrillaris is responsible for hundreds of reported cases of amoebic encephalitis, the majority of which have been fatal. Despite being an exceptionally deadly pathogen, B. mandrillaris is understudied, leaving many open questions regarding epidemiology,… read more here.
Keywords: balamuthia mandrillaris; treatment; mandrillaris infections; nitroxoline ... See more keywords
A patient with granulomatous amoebic encephalitis caused by Balamuthia mandrillaris survived with two excisions and medication
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DOI: 10.1186/s12879-021-07020-8
Abstract: Background Granulomatous amoebic encephalitis (GAE) is a rare central nervous system infection caused by the Balamuthia mandrillaris or Acanthamoeba species. Diagnosis is challenging because of the non-specific clinical presentation, cerebrospinal fluid analysis, and radiological features.… read more here.
Keywords: mandrillaris; caused balamuthia; patient; amoebic encephalitis ... See more keywords
Diagnosis of Balamuthia mandrillaris Encephalitis by Thymine-Adenine Cloning Using Universal Eukaryotic Primers
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DOI: 10.3343/alm.2022.42.2.196
Abstract: Background Identifying the causal pathogen of encephalitis remains a clinical challenge. A 50-year-old man without a history of neurological disease was referred to our department for the evaluation of an intracranial lesion observed on brain… read more here.
Keywords: adenine cloning; mandrillaris; universal eukaryotic; encephalitis ... See more keywords
An Optical and Chemiluminescence Assay for Assessing the Cytotoxicity of Balamuthia mandrillaris against Human Neurospheroids
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DOI: 10.3390/bioengineering9070330
Abstract: A spheroid is a cell aggregate in a three-dimensional context; thereby, it recapitulates the cellular architecture in human tissue. However, the utility of spheroids as an assay for host–parasite interactions remains unexplored. This study demonstrates… read more here.
Keywords: balamuthia mandrillaris; mandrillaris; assessing cytotoxicity; optical chemiluminescence ... See more keywords
Molecular Diagnosis of Encephalitis/Meningoencephalitis Caused by Free-Living Amoebae from a Tertiary Center in India
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DOI: 10.3390/pathogens11121509
Abstract: Background: Pathogenic free-living amoeba (FLA) such as Acanthamoeba spp., Naegleria fowleri, and Balamuthia mandrillaris are causative agents of fatal amoebic encephalitis/meningoencephalitis. The diagnosis of such infections is challenging due to a lack of clinical suspicion… read more here.
Keywords: mandrillaris; microscopy; acanthamoeba spp; encephalitis meningoencephalitis ... See more keywords