Involvement of gap junctions in astrocyte impairment induced by manganese exposure
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2018.04.009
Abstract: Glutamate excitotoxicity, characterized as excessive glutamate stress, is considered to be involved in cerebral ischaemia, brain trauma, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Glutamate homeostasis disruption was highlighted in Mn neurotoxicity… read more here.
Keywords: gap; gap junctions; glutamate; exposure ... See more keywords
Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2017.05.009
Abstract: HighlightsMn induces mitochondrial dysfunction in astrocytes.Mn exposure induces inflammatory response in astrocytes and exacerbates &agr;Synagg‐induced inflammatory response in astrocytes.Mito‐apocynin attenuates Mn‐induced inflammatory response in astrocytes by reducing mitochondrial damage.Intranasal Mn exposure induces neuroinflammation and behavioral… read more here.
Keywords: inflammatory response; exposure; exposure induces; manganese exposure ... See more keywords
Biomarkers of environmental manganese exposure
Sign Up to like & getrecommendations! Published in 2022 at "Critical Reviews in Toxicology"
DOI: 10.1080/10408444.2022.2095979
Abstract: Abstract We conducted a critical review on biomarkers of environmental manganese (Mn) exposure to answer the following questions: 1) are there reliable biomarkers of internal Mn exposure (Mn in biological matrices) associated with external metrics… read more here.
Keywords: toxicology; biomarkers environmental; manganese exposure; environmental media ... See more keywords
The mitochondrial RNA granule modulates manganese-dependent cell toxicity
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1101/2022.01.04.474973
Abstract: Prolonged manganese exposure causes manganism, a neurodegenerative movement disorder. The identity of adaptive and non-adaptive cellular processes targeted by manganese remains mostly unexplored. Here we study mechanisms engaged by manganese in genetic cellular models known… read more here.
Keywords: mitochondrial rna; manganese exposure; rna granule; granule ... See more keywords
Early postnatal manganese exposure causes arousal dysregulation and lasting hypofunctioning of the prefrontal cortex catecholaminergic systems
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14934
Abstract: Studies have reported associations between environmental manganese (Mn) exposure and impaired cognition, attention, impulse control, and fine motor function in children. Our recent rodent studies established that elevated Mn exposure causes these impairments. Here, rats… read more here.
Keywords: catecholaminergic systems; exposure causes; exposure; manganese exposure ... See more keywords
1655b The usefulness of biological monitoring in determining manganese exposure in the workplace
Sign Up to like & getrecommendations! Published in 2018 at "Occupational and Environmental Medicine"
DOI: 10.1136/oemed-2018-icohabstracts.1446
Abstract: Introduction Exposure to manganese in the workplace is an occupational health concern, it is known that even at relatively low levels of exposure subtle neurological effects have been observed in workers (Baker, et al., 2014).… read more here.
Keywords: samples collected; determining manganese; exposure; air ... See more keywords
Manganese Exposure Aggravates β-Amyloid Pathology by Microglial Activation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2020.556008
Abstract: Human epidemiological evidence and animal experimental data suggest that chronic manganese (Mn) exposure increases the risk of Alzheimer’s disease (AD) and amyloid plaques, a hallmark of AD brain pathology, but the underlying mechanisms were not… read more here.
Keywords: exposure aggravates; cultured microglia; exposure; pathology ... See more keywords
Development of a Cumulative Exposure Index (CEI) for Manganese and Comparison with Bone Manganese and Other Biomarkers of Manganese Exposure
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph15071341
Abstract: Manganese (Mn) exposure can result in parkinsonism. However, understanding of manganese neurotoxicity has been limited by the lack of a cumulative Mn biomarker. Therefore, the current goal was to develop Mn cumulative exposure indices (MnCEI),… read more here.
Keywords: development cumulative; cumulative exposure; exposure; bone ... See more keywords