Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease
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DOI: 10.1172/jci.insight.140978
Abstract: ZIP8 is a metal transporter with a role in manganese (Mn) homeostasis. A common genetic variant in ZIP8 (rs13107325; A391T) ranks in the top 10 of pleiotropic SNPs identified in GWAS; A391T has associations with… read more here.
Keywords: zip8 a391t; disease; zip8; manganese homeostasis ... See more keywords
The Functions of ZIP8, ZIP14, and ZnT10 in the Regulation of Systemic Manganese Homeostasis
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DOI: 10.3390/ijms21093304
Abstract: As an essential nutrient, manganese is required for the regulation of numerous cellular processes, including cell growth, neuronal health, immune cell function, and antioxidant defense. However, excess manganese in the body is toxic and produces… read more here.
Keywords: homeostasis; zip8 zip14; znt10; manganese homeostasis ... See more keywords