Familial manganese-induced neurotoxicity due to mutations in SLC30A10 or SLC39A14.
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2017.07.030
Abstract: Over the last few years, two rare, familial diseases that lead to the onset of manganese (Mn)-induced neurotoxicity have been discovered. Loss-of-function mutations in SLC30A10, a Mn efflux transporter, or SLC39A14, a Mn influx transporter,… read more here.
Keywords: mutations slc30a10; familial manganese; induced neurotoxicity; manganese induced ... See more keywords
Manganese chloride induces histone acetylation changes in neuronal cells: Its role in manganese‐induced damage
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DOI: 10.1016/j.neuro.2017.11.003
Abstract: Graphical abstract Manganese chloride may inhibit the acetylation of histone H3 and H4 by increasing the activity of HDAC, and decreasing that of HAT, which finally caused the cell damage and apoptosis in neuronal cells.… read more here.
Keywords: manganese chloride; histone acetylation; neuronal cells; acetylation ... See more keywords
Manganese-induced trafficking and turnover of GPP130 is mediated by sortilin
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DOI: 10.1091/mbc.e17-05-0326
Abstract: By binding and directing the cycling Golgi protein GPP130 to lysosomes, the sorting receptor sortilin mediates the manganese-induced GPP130 down-regulation that protects against Shiga toxicosis. read more here.
Keywords: turnover gpp130; gpp130; induced trafficking; manganese induced ... See more keywords
Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies
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DOI: 10.3389/fphar.2022.1011947
Abstract: Chronic exposure to elevated levels of manganese via occupational or environmental settings causes a neurological disorder known as manganism, resembling the symptoms of Parkinson’s disease, such as motor deficits and cognitive impairment. Numerous studies have… read more here.
Keywords: induced neurotoxicity; manganese neurotoxicity; factor; mechanisms manganese ... See more keywords