α‐Mangostin protects lipopolysaccharide‐stimulated nucleus pulposus cells against NLRP3 inflammasome‐mediated apoptosis via the NF‐κB pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4306
Abstract: Intervertebral disc degeneration (IDD) is a common and chronic inflammatory disorder. α‐Mangostin exhibits a novel biological function against inflammation in various inflammatory diseases. Here, we aimed to explore the role of α‐mangostin in IDD using… read more here.
Keywords: apoptosis; expression; mangostin; nucleus pulposus ... See more keywords
α‐Mangostin attenuates stemness and enhances cisplatin‐induced cell death in cervical cancer stem‐like cells through induction of mitochondrial‐mediated apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29489
Abstract: Cancer stem cells (CSCs) exhibit specific characteristics including decontrolled self‐renewal, tumor‐initiating, promoting, and metastatic potential, abnormal stemness signaling, and chemotherapy resistance. Thus, targeting CSC is becoming an emerging cancer treatment. α‐Mangostin has been shown to… read more here.
Keywords: csc; csc like; apoptosis; cervical cancer ... See more keywords
Structural alterations in the catalytic core of hSIRT2 enzyme predict therapeutic benefits of Garcinia mangostana derivatives in Alzheimer's disease: molecular dynamics simulation study
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d0ra10459k
Abstract: Recent studies have shown that inhibition of the hSIRT2 enzyme provides favorable effects in neurodegenerative diseases such as Alzheimer's disease. Prenylated xanthone phytochemicals including α-mangostin, β-mangostin and γ-mangostin obtained from Garcinia mangostana, a well-established tropical… read more here.
Keywords: alzheimer disease; catalytic core; hsirt2 enzyme; mangostin ... See more keywords
Antibacterial and anti-biofilm effects of a polyherbal formula and its constituents against coagulase-negative and -positive staphylococci isolated from bovine mastitis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Applied Animal Research"
DOI: 10.1080/09712119.2016.1193021
Abstract: ABSTRACT Concerns about antibiotic residues in milk and emergence of antimicrobial resistant pathogens necessitate exploration of alternative therapeutic strategies for the treatment of mastitis. This study aims to investigate anti-infective properties of a Thai traditional… read more here.
Keywords: polyherbal formula; mastitis; bovine mastitis; anti biofilm ... See more keywords
Mucoadhesive chitosan and thiolated chitosan nanoparticles containing alpha mangostin for possible Colon-targeted delivery
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2021.1873370
Abstract: Abstract α-Mangostin-loaded mucoadhesive nanoparticles (NPs) were prepared for colon-targeted drug delivery against colorectal cancer cells using pH-dependent composite mucoadhesive NPs. Chitosan (CS) and thiolated chitosan (TCS) were used to form the NPs, following by genipin… read more here.
Keywords: chitosan thiolated; delivery; colon targeted; thiolated chitosan ... See more keywords
In vitro assays in natural products research – a matter of concentration and relevance to in vivo administration using resveratrol, α-mangostin/γ-mangostin and xanthohumol as examples
Sign Up to like & getrecommendations! Published in 2017 at "Natural Product Research"
DOI: 10.1080/14786419.2016.1190721
Abstract: Abstract Herbal or botanical dietary supplements are an ever increasingly popular category of products in the United States and around the world. In vitro data can provide meaningful insight into the potential target and mechanism… read more here.
Keywords: administration; research; mangostin mangostin; mangostin xanthohumol ... See more keywords
Water-dispersible unadulterated α-mangostin particles for biomedical applications
Sign Up to like & getrecommendations! Published in 2020 at "Royal Society Open Science"
DOI: 10.1098/rsos.200543
Abstract: α-Mangostin, the extract from pericarp of Garcinia mangostana L. or mangosteen fruit, has been applied in various biomedical products because of its minimal skin irritation, and prominent anti-inflammatory, antimicrobial and immune-modulating activities. Owing to its… read more here.
Keywords: dispersible unadulterated; water; conventional mangostin; mangostin particles ... See more keywords
Alpha-Mangostin-Loaded Transferrin-Conjugated Lipid-Polymer Hybrid Nanoparticles: Development and Characterization for Tumor-Targeted Delivery
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DOI: 10.1155/2022/9217268
Abstract: Alpha-mangostin, a natural xanthone mainly extracted from the pericarp of Garcinia mangostana, has been shown to have promising anticancer properties in many types of cancer. However, the therapeutic potential of α-mangostin has been limited so… read more here.
Keywords: alpha mangostin; lphn; transferrin conjugated; mangostin ... See more keywords
Protective effect of alpha-mangostin on thioacetamide-induced liver fibrosis in rats as revealed by morpho-functional analysis.
Sign Up to like & getrecommendations! Published in 2019 at "Histology and histopathology"
DOI: 10.14670/hh-18-052
Abstract: Liver fibrosis is an excessive accumulation of scar tissue resulting from inflammation and cell death. Thioacetamide (TAA) is a well-known hepatotoxin that induces liver fibrosis. A marker of injured hepatocytes is transforming growth factor-beta 1… read more here.
Keywords: effect; alpha mangostin; liver fibrosis; mangostin ... See more keywords
Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone
Sign Up to like & getrecommendations! Published in 2019 at "Oncotarget"
DOI: 10.18632/oncotarget.27159
Abstract: Given that colon cancer is the third most common cancer in incidence and cause of death in the United States, and current treatment modalities are insufficient, there is a need to develop novel agents. Towards… read more here.
Keywords: tcf4; transcription factor; colon cancer; mangostin ... See more keywords
Cytotoxic and Antiproliferative Effects of β-Mangostin on Rat C6 Glioma Cells Depend on Oxidative Stress Induction via PI3K/AKT/mTOR Pathway Inhibition
Sign Up to like & getrecommendations! Published in 2020 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s278414
Abstract: Background Glioma is the most common malignant tumor of the nervous system, which accounts for more than 45% of central nervous system tumors and seriously threatens our health. Because of high mortality rate, limitations, and… read more here.
Keywords: mangostin; glioma; glioma cells; pi3k akt ... See more keywords