Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D2R-mediated Sleep Reduction
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101240
Abstract: Summary Individuals with the neuropsychiatric disorder mania exhibit hyperactivity, elevated mood, and a decreased need for sleep. The brain areas and neuronal populations involved in mania-like behaviors, however, have not been elucidated. In this study,… read more here.
Keywords: mania like; dopamine; like behaviors; sleep reduction ... See more keywords
CRMP2 mediates GSK3β actions in the striatum on regulating neuronal structure and mania-like behavior.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2018.10.371
Abstract: BACKGROUND Genetic and physiological studies have implicated the striatum in bipolar disorder (BD). Although Glycogen synthase kinase 3 beta (GSK3β) has been suggested to play a role in the pathophysiology of BD since it is… read more here.
Keywords: mania like; crmp2; like behavior; structure ... See more keywords
Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-00958-2
Abstract: Valproate (VPA) has been used in the treatment of bipolar disorder since the 1990s. However, the therapeutic targets of VPA have remained elusive. Here we employ a preclinical model to identify the therapeutic targets of… read more here.
Keywords: reverses mania; mania like; valproate reverses; valproate ... See more keywords
Chronic lithium treatment ameliorates ketamine-induced mania-like behavior via the PI3K-AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Zoological Research"
DOI: 10.24272/j.issn.2095-8137.2022.278
Abstract: Ketamine, a rapid-acting antidepressant drug, has been used to treat major depressive disorder and bipolar disorder (BD). Recent studies have shown that ketamine may increase the potential risk of treatment-induced mania in patients. Ketamine has… read more here.
Keywords: mania like; ketamine; induced mania; ketamine induced ... See more keywords
Effects of Dexamethasone and Pentoxifylline on Mania-like and Depression-like Behaviors in Rats
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DOI: 10.3390/ph15091063
Abstract: Several studies support the notion that inflammation plays a role in the pathophysiology and treatment approaches of psychiatric illnesses, particularly mood disorders. Congruently, classic anti-inflammatory drugs were found efficacious in randomized clinical trials of patients… read more here.
Keywords: mania like; like behaviors; dexamethasone pentoxifylline; pentoxifylline mania ... See more keywords
ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.39907
Abstract: Dysfunction of the noradrenergic (NE) neurons is implicated in the pathogenesis of bipolar disorder (BPD). ErbB4 is highly expressed in NE neurons, and its genetic variation has been linked to BPD; however, how ErbB4 regulates… read more here.
Keywords: mania like; locus coeruleus; erbb4 deletion; deletion noradrenergic ... See more keywords