A bacterial effector manipulates host lysosomal protease activity–dependent plasticity in cell death modalities to facilitate infection
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2406715122
Abstract: Significance Mammalian hosts coordinate various cell death pathways as part of defense system against pathogens including Mycobacterium tuberculosis (Mtb), which causes tuberculosis featured with lung inflammation and necrosis. However, how Mtb manipulates host molecular switches… read more here.
Keywords: protease; cell; death modalities; manipulates host ... See more keywords
Human coronavirus 3CL protease manipulates host protein STIM1 to facilitate immune evasion.
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2503436122
Abstract: Coronaviruses rely on intricate interactions with host proteins to create an environment conducive to their replication and survival. The 3CL protease of coronavirus acts as a key mediator, serving a dual role in cleaving viral… read more here.
Keywords: manipulates host; 3cl protease; protease manipulates; protease ... See more keywords